「脳MRI かっこいい」の画像検索結果「関節炎 画像」の画像検索結果http://cfnewsads.thomasnet.com/images/large/525/525971.jpgMedicine Ⅲ(Neurology and Rheumatology)Medicine ⅢAmyloidosisChief：prof. Yoshiki Sekijima Summary of ActivityDepartment of Medicine (Neurology and Rheumatology) is focusing on the development ofskills to explore the patients’ whole body.In the Neurology area, our target is total nervous system of the whole body which consist ofthe brain, spine, peripheral nerve, and muscles. There are many neurological disorders whichdo not show any abnormality in blood tests or imaging examination. Therefore itis veryimportant to make a correct diagnosis through the whole body physical examinations andneurological examinations.In the Rheumatology area, we see the patients with connective tissue disorders which mainlyinvolve the whole body joints. You might be able to get the ability to find abnormal joints bytouching and feeling the patients’ joints by your own hands.Amyloidosis is a disorder characterized by the deposition of abnormal protein called ‘amyloid’into the whole body, such as the brain, heart, kidney, liver, digestive tract, peripheral nervoussystem, muscles, and endocrine systems. These visceral organs are also involved among thepatients with rheumatic diseases.Therefore, you may get the specialized skills as an neurologist andrheumatologist and also get the general skills to see and managethe patients’ whole body issue.See following pages to check the details of our research works.ChiefChief of Neurology: Yoshiki Sekijima (professor)Chief of Rheumatology: Yasuhiro Shimojima (associate professor)Division 1. Amyloidosis team2. Brain Disease Research team3. Muscle disease research team4. Rheumatology, Clinical immunology teamAmyloidosis is an intractable disease in which abnormal protein,into multi visceral organs and causecalled ‘’amyloid’’, depositorgan dysfunction.It is sometimes very difficult to diagnose and/or treat amyloidosisappropriately. Our department is one of the leading amyloidosiscenter in the nation, providing total services such as diseaseconsultation, diagnosis, research, and treatment, especially in thefield of two major types of amyloidosis, ATTR and AL amyloidosis.Research subjectOutlook for researchOutlook for students after graduationUpper: Amyloid deposition in endocrine tumor and peptide gained by LMD was part of somatostatinLeft Lower: the methods of LMD・Evaluation of Disease-Maker and pharmacological treatment for ATTRmamyloidosis.・AL amyloidosis treatment using novel chemotherapeutic agents.・Development of whole body amyloid imaging technique using PiB-PET .・Neurophysiological evaluation and analysis of amyloid neuropathy.・Detection of rare types of amyloidosis using laser micro dissection and mass spectrometry.Much common diseases such as Alzheimer Disease and type 2diabetes are other kinds of amyloidosis. Our research works might leadto unveiling and overcoming of these popular diseases as well as akind of rare types of amyloidosis.The both ways to a brilliant future as generalist and/or amyloidosisspecialist are provided. We evaluated the reduction of intensity of PiB-PET in heart after complete regression with chemo-theraphy (Oguchi、Katoh.Amyloid 2023）We revealed the progression of ATTR cerebral amyloid angiopathy by using PET（Takahashi Amyloid 2023）We revealed the novel amyloidosis of somatostatin by using Laser micro dissection(LMD) and tandem LC-MS（Ichimata、Katoh Amyloid 2022）M：月 11 Explore the whole body!Be generalist with specialized skills!Leading amyloidosis center in Japan
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