医学科研究紹介_英語版_2024_2025
17/48

We evaluated the reduction of intensity of PiB-PET in heart after complete regression with chemo-theraphy(Oguchi、Katoh.Amyloid 2023)We revealed the progression of ATTR cerebral amyloid angiopathy by using PET(TakahashiAmyloid 2023)Upper: Amyloid deposition in endocrine tumor and peptide gained by LMD was part of somatostatinLeft Lower: the methods of LMDWe revealed the novel amyloidosis of somatostatin by using Laser micro dissection(LMD) and tandem LC-MS(Ichimata、KatohAmyloid 2022)M:月MedicineⅢMedicineⅢAmyloidosis12(Neurology and Rheumatology)▶SummaryofActivity▶ChiefChiefofNeurology:YoshikiSekijima(professor)ChiefofRheumatology:YasuhiroShimojima(associateprofessor)▶DivisionChief:prof.YoshikiSekijimaResearch subjectOutlook for students after graduationThebothwaystoabrilliantfutureasgeneralistand/oramyloidosisspecialistareprovided.Explore the whole body!Be generalist with specialized skills!Leading amyloidosis center in JapanDepartmentofMedicine(NeurologyandRheumatology)isfocusingonthedevelopmentofskillstoexplorethepatients’wholebody.IntheNeurologyarea,ourtargetistotalnervoussystemofthewholebodywhichconsistofthebrain,spine,peripheralnerve,andmuscles.Therearemanyneurologicaldisorderswhichdonotshowanyabnormalityinbloodtestsorimagingexamination.Thereforeitisveryimportanttomakeacorrectdiagnosisthroughthewholebodyphysicalexaminationsandneurologicalexaminations.IntheRheumatologyarea,weseethepatientswithconnectivetissuedisorderswhichmainlyinvolvethewholebodyjoints.Youmightbeabletogettheabilitytofindabnormaljointsbytouchingandfeelingthepatients’jointsbyyourownhands.Amyloidosisisadisordercharacterizedbythedepositionofabnormalproteincalled‘amyloid’intothewholebody,suchasthebrain,heart,kidney,liver,digestivetract,peripheralnervoussystem,muscles,andendocrinesystems.Thesevisceralorgansarealsoinvolvedamongthepatientswithrheumaticdiseases.Therefore,youmaygetthespecializedskillsasanneurologistandrheumatologistandalsogetthegeneralskillstoseeandmanagethepatients’wholebodyissue.Seefollowingpagestocheckthedetailsofourresearchworks.Amyloidosisisanintractablediseaseinwhichabnormalprotein,called‘’amyloid’’,depositintomultivisceralorgansandcauseorgandysfunction.Itissometimesverydifficulttodiagnoseand/ortreatamyloidosisappropriately.Ourdepartmentisoneoftheleadingamyloidosiscenterinthenation,providingtotalservicessuchasdiseaseconsultation,diagnosis,research,andtreatment,especiallyinthefieldoftwomajortypesofamyloidosis,ATTRandALamyloidosis.・Evaluation of Disease-Maker and pharmacological treatment for ATTRmamyloidosis.・AL amyloidosis treatment using novel chemotherapeutic agents.・Development of whole body amyloid imaging technique using PiB-PET .・Neurophysiological evaluation and analysis of amyloid neuropathy.・Detection of rare types of amyloidosis using laser micro dissection and mass spectrometry.Outlook for researchMuchcommondiseasessuchasAlzheimerDiseaseandtype2diabetesareotherkindsofamyloidosis.Ourresearchworksmightleadtounveilingandovercomingofthesepopulardiseasesaswellasakindofraretypesofamyloidosis.1.Amyloidosisteam2.BrainDiseaseResearchteam3.Musclediseaseresearchteam4.Rheumatology,Clinicalimmunologyteam2024-2025医学科研究紹介

元のページ  ../index.html#17

このブックを見る