BDCNozawanaTLRsDendritic cellsResveratrol (Res)Changes in bacterial flora and immunoregulatory effectsIL-12NK activityCytokineInputPull down+++++−+Immunostimulatory effectIFN-gKeywords;FoodimmunologyDendriticcellsTcellsIFN-gammaResearchkeywords:Obesity-associateddiseases,Adipogenesis,Adipokines,AdipocytedifferentiationFoodfactors,Foodfunctions,Weareplanningtoexaminetheeffectsoffoodcomponentsanddietaryhabitsonimmunefunctionsandelucidatemolecularmechanismsofimmuneregulation.Moreover,weareaimingfortheinvestigationofunknownimmune-modulatingeffectsofcompoundsderivedfromfoods,andidentificationoffunctionalcomponentstopreventimmune-relateddiseasessuchasinfectiousdisease,cancer,andallergy.Thesestudieswillleadtoapplicationforfunctionalfoodsexhibitingimmuneregulatingeffects.Immunostimulatory effects of NozawanaBrassicarapaL.,knownasNozawanainJapan,isacruciferousplantandatraditionalvegetableoftheShinshuanimmunostimulatoryeffectbyenhancinginterferongammaproductionandnaturalkilleractivity.DuringthefermentationofNozawana,thenumberoflacticacidbacteriaincreasedandcytokineproductionbyspleencellsisenhanced.Thus,Nozawanacouldbeapromisingfoodforimprovinghumanhealth.ImmuneregulationbydietarypolyphenolsProcyanidin,adietarypolyphenolispresentinfood.WehavereportedthatPCB23,3′′-di-O-gallate(PCB2DG),whichcontainstwogallategroups,markedlyinhibitedtheproductionofproinflammatorycytokinesfromimmunecells.Furthermore,wehaveshownthatPCB2DGamelioratedtheinflammatorydiseasesusingmousemodels.Obesityisoneoftheriskfactorsfortype2diabetesandcardiovasculardiseases,andalsodementia.Thus,wefocusonobesitytopreventtheabove-mentioneddiseases.Analysisofmolecularmechanismofanti-obesitytheidentificationofthemoleculartargetsoftheseactivecompounds.compounds,activeDevelopment of a therapeutic agent for obesity and obesity-associated diseases.area.Nozawanaexertedcompound,and12SachiTANAKAAssociateProfessor,Ph.D.TheresearchinterestsoftheLaboratoryofFoodSciencefocusonthediscoveryanddevelopmentofNutraceuticalsandnovelactivecompoundsthatcanbeusedfordrugsorfunctionalfoods.Inaddition,wechallengetoidentifymoleculartargetsoffoodfactorsthatareeffectiveagainstobesityandits-associateddiseases.Ourlaboratoryaimtodevelopcreativescientistthatcontributestosocietythroughresearchandeducation.TakakazuMITANIAssistantProfessor,Ph.D.Variousbacteria Immune cellsDifferentiation to adipocytes3T3-L1 cells are model of adipocytes. We have searched the anti-adipogenesis and anti-obesity compounds using this cells.Furthermore, we have characterized molecular target in adipocytes for active compound against obesity.Fermentation of NozawanaLactic acid bacteria Cell lysatesRes-bound resinResNozawanaBpickleNozawanaFood Science and Biotechnology DivisionFood Science and Biotechnology DivisionLaboratory of Food ImmunologyLaboratory ofFood Function
元のページ ../index.html#16