（Chief：Prof. Takafumi Naito）40Research subjectOutlook for researchOutlook for students after graduation・Development of quantitative methods of drugs in human biological samples・Evaluation of inter-individual variations in clinical responses to drugs・Construction of rational pharmacotherapy for the disease and its conditions・Detection of unknown adverse events and drug-drug interactions using non-experimental methodsClarification of patient factors related to the pharmacokinetics, drug efficacy, and adverse reactions contributes to the individualization of pharmacotherapy. Our achievements lead to the construction of the rational pharmacotherapy for the disease and its conditions.After receiving an academic degree, a lot of our laboratory graduates work as a clinical phar-macist or researcher. Some graduates can be engaged in the drug discovery research and development at a pharmaceutical company.TDM of cetuximab (anti-EGFR antibody) in head and neck cancer patients（Shibata K, et al. Cancer Chemother Pharmacol. 2021;87:555-65）Optimization of individual pharmacotherapy based on the multiple evaluation of patient information（Naito T. Biol Pharm Bull 2019;42:149-57）Summary of ActivityOur department creates the drug information for implementing the rational pharmacotherapy in clinical settings. For the goal, we develop the quantitative methods of drugs in human biological samples using a liquid chromatograph coupled to mass spectrometer. The present projects quantitatively evaluate the inter-individual variations in clinical responses to drugs from the viewpoints of pharmacokinetics and pharmacodynamics. We finally aim to construct the ratio-nal pharmacotherapy based on the factors related to the clinical responses to drugs for each disease and its condition.Clinical Pharmacology and TherapeuticsCreating the drug information for implementing the rational pharmacotherapy in clinical settings
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