・Development of new drugs for malignant bone tumors・Analysis of sugar chain-related gene expression in malignant soft tissue tumors ・Evaluation of bone morphology using CT images・ Lower limb muscle strength and predictive postoperative function of patients with malig-29nant soft tissue tumorsOutlook for researchResearch subjectOutlook for students after graduationCancer research in the orthopedic field is relatively underdeveloped compared to other areas of oncology, and research themes remain abundant. By establishing new therapeutic drugs and treatment systems, we can still help to “create the future” of patients suffering from can-cer.Because few doctors specialize in orthopedic oncology, learning in this group can provide the potential for you to become an expert in both research and clinical fields. You can aim to become doctors and researchers who can be actively engaged with the world.during surgery for function preservationGraduate students studying on a daily basis for the development of new therapeutic drugsBone morphology analysis using CT im-ages to predict fracture riskMuscle force measurement using hand held dynamometer/isokinetic dynamome-terOncology GroupOncology Group(Chief:Masanori Okamoto, Assistant Professor(Chief:Masanori Okamoto, Assistant Professor））Summary of ActivityAt the Department of Neurosurgery, Shinshu University School of Medicine, we conduct surgical treatment for cerebrovascular disorder, brain tumors, epilepsy, etc. with a consistent treatment policy using “as less as reasonable achievable (ALARA) surgery and function pres-ervation therapy” by making full use of state-of-the-art medical care. The goal is to cultivate more excellent neurosurgeons by performing high level brain surgical interventions in collaboration with all affiliated hospitals. For each neurosurgical disease, we are conducting research on the following themes:・ Minimally invasive surgical approach: Development of surgical methods and safer surgical approach for the skull base lesion・ Surgical instrument: Development of surgical instruments to make surgery safer and more reliable ・ Surgical simulation: Development of surgical simulation with three dimensional neuro-images・ Microneurosurgical anatomical study: Understanding and study of focal brain anatomy for more precise neurosurgical operation・ Intraoperative neural function monitoring and mapping: Research on evaluation of neural functions using electrophysiological techniques ・ Development of surgical robotics: Development of robot-assisted surgery system for minimally invasive neurosurgery・ Genetic analysis of malignant brain tumor: Genetic analysis, optimal chemotherapy of the malignant brain tumorSummary of ActivityCancers in the orthopedic field are often called “rare cancers” because of their low frequency of occurrence and small number of cases. As a result of their rari-ty, the development of diagnostic / therapeutic methods is still lagging, and many patients face unfortunate consequences. Shinshu University is engaged in the development of new therapeutic agents for malignant bone tumors, methods to efficiently deliver anticancer agents o tumors, and new diagnostic criteria for ma-lignant soft tissue tumors. In the clinical field, we are studying bone morphology evaluation using CT images for the prevention of pathological fractures due to bone metastasis and lower limb muscle strength, in addition to the prediction of postoperative function in patients with malignant soft tissue tumors.Divisions: 1. Cerebrovascular neurosurgery 2. Brain tumor (intra- and extraaxial) 3. Epilepsy surgery 4. Neuroendoscopic surgery 5. Endovascular treatmentOrthopaedic SurgeryNeurosurgeryFor the future of patients suffering from rare cancersMinimally invasive (ALARA) and function preservation neurosurgical treatment using the state-of-the-art medical care
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