25Research subjectOutlook for students after graduation・To solve perioperative and long-term problems associated with liver transplantation・Simulation training to improve islet isolation techniques ・To investigate how to protect pancreatic isletsOutlook for research・ Appling knowledge of our over 20 years of practice to improve the outcome after liver ・To promote islet transplantation therapy in Japan along with other institutionsOutlook for students after graduation・ To become a transplant surgeon having a deep knowledge of immune system, cell protec-transplantationtion, and patient care.recombinant bifidobacteriaIn medicine, it is said that today’s contraindications are tomorrow’s indications.Things that are forbidden today because something cannot be overcome may be permitted tomorrow thanks to just one breakthrough.We run practical training programs with specific goals that include understanding all charged cases and diseases, learning basic surgical procedures, and improving presentation tech-niques.* Health, Labour and WelfareThe upper graph is Kaplan-Meier patient survival curve. The over all survival in a total of 39 cases for recent seven years was 95%. State of cardiac surgeryCardiac regenerative therapy using iPS cell.“Modified from Shiba, et al. Nature 2016; 538: 388-391.”Islets for islet transplantationIslets (stained on red) isolated from a donor’s pancreas are transplanted into the liver through the portal vein.novel site-selective ischemic disease therapeutic using recombinant bifidobac-teriaCardiovascular SurgeryCardiovascular SurgerySummary of Activity・ The first case of living donor liver transplantation in our institute was per-formed in 1990, and more than 300 cases have been experienced. We will continue to provide careful patient care to overcome life threatening problems, such as rejection, infection, and de novo cancer after transplantation. ・ For clinical islet transplantation program, our institution is approved by Minister for HLW* to provide Class I Regenerative Medicine under the Act on the Safe-ty of Regenerative Medicine in 2015.Research subjectSummary of ActivityWe are conducting surgical treatment for cardiovascular diseases, peripheral vascular diseases including venous and lymphatic vessels, from heart disease to peripheral organs in the body as a whole. Particularly in multidisciplinary therapy for patients with severe systemic complications, elderly patients, patients with complex lesions, taking advantage of the university hospital, we offer medical treatment aiming for safer and more reliable surgery considering the patient’s long-term prognosis.・ Research and development of cardiac regenerative therapy using iPS cell.・ Research and development of surgery for thoracoabdominal aneurysm.・ Research and development of novel site-selective ischemic disease therapeutic using ・ Research and development of cardiac allograft rejection Outlook for research（（Prof. Tatsuichiro SetoProf. Tatsuichiro Seto））SurgeryExploring perioperative and long-term problems associated with liver transplantation Promoting pancreatic islet cell transplantationTo offer the most appropriate and advanced care for the patientsSurgery(Gastroenterological)Transplant and Pediatric SurgeryTransplant and Pediatric Surgery（（Chief: Senior Assistant Prof. Atsuyoshi MitaChief: Senior Assistant Prof. Atsuyoshi Mita））
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