（Chief: Prof. Hiroyuki Kanno）・Collagen disease, vasculitis, glomerulonephritis: Contribution of innate immunity activated by various microorganisms・Epstein-Barr virus-related diseases: Diseases caused by ubiquitous virus in human beings in specific conditions・ Prevention and treatment of intractable diseases caused via immune mechanisms・ Lower frequency of complications caused with immune suppression in patients receiving ・Biomedical research positions in pathology department in medical school・Beneficial experiences in the research of human diseases・Diagnostic pathologists in pathology department in center hospitals8Research subjectResearch subjectOutlook for researchOutlook for students after graduationOutlook for research・ Pharmacological treatment of pediatric heart failure・ Mechanisms supporting the circulatory transition before weaning・ Pharmacological prevention of Sudden Infant Death Syndrome・ Pharmacological differentiation of low-birth-weight infants’ kidneyThere are few drugs specific for pediatric diseases because most of them are rare and not suitable for large clinical trials. However, children are not ‘miniature adults’ and can suffer from serious adverse effects of adult drugs. Our research would shed light on this inconvenient fact.You can learn multidisciplinary approach including molecular biology to comparative integra-tive physiology in this laboratory. This will help you to win the competition in getting your next good scientific position.advanced medical careOutlook for students after graduationKashihara, T., Kawagishi, H. et al. (2020) JACC: BTS 5: 1057-69 Training in diagnostic pathologyMan-to-man training with senior staffObservation of cultured cellsunder inverted microscopeBroad research approachnot restricted in morphologySummary of ActivityHeart failure is the condition in which heart dysfunction results in insufficient distribution of oxygen and nutrients to peripheral organs. Pediatric heart failure is an important cause of death in children. Especially overt heart failure presenting in the infant period are malignant and fulminant. Surprisingly, however, there are no specific drugs available for them. We are seeking for drugs that enable these children to survive safely through the long waiting time for cardiac transplanta-tion.Summary of ActivityPathology, an unfamiliar research field, clarifies the disease process to death. Pathologists observe the tissue specimens sampled from the lesion of patients, give the diagnosis and further make final diagnosis after autopsy examination. They contribute to the advanced medicine through conferences with clinicians. Pathology, research of etiopathogenesis of diseases, makes the bases of pathologic diagnosis. In our department, we can devote in advanced biomedical research with the pride of physician engaged in patient care.Drug for Pediatric Heart FailureResearch of EtiopathogenesisMolecular Pharmacology（Chief: Prof. Mitsuhiko Yamada）Pathology
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