CImmunostainingofskeletalmusclestemcellsduringmyogenicdifferentiationinculture.自動収穫機によって根が均一に切断されたホウレンソウABDBCADBCA4Day 0Day 1Bioinformaticanalysisofbindingsitesofmyogenictranscriptionfactors.After collecting mushroom genetic resources, isolating mycelial cultures, and preserving mushroom strains, we are developing superior cultivars using the strains.A: Students are performing mushroom genetic studies in the laboratory. B: Protoplasts from Pleurotus ostreatusC: DNA fingerprints for Flammulina velutipesDay 2Day 3thegenome-wideDNA-1. Collection of mushroom genetic resources4. Evaluation ofgenetic resources3. Preservation of mushroom genetic resourcesC2. Mycelium isolation culture5. Selection of superior cultivars•Stem cell biology•Skeletal muscle•Myogenic differentiation•Regenerative medicine•Transcription factor•Mushroom genetics•Mushroom breeding•Mushroom phylogeny•Genetic resources•Mutant strainsMuscledistinguishesanimals.Wecanmoveaswewantbymusclefunctions.Higheranimalshavethreetypesofmuscles;cardiac,smooth,andskeletalmuscles.Ourmovementscanberealizedbycooperationofthreemuscles.Thesemusclecellsareverysimilar,inthesameway,quitedifferent.Oneofourinterestsisthemechanismwhichenablesmusclediversity.Forhealthylongevity,allmusclesshouldbemaintainedhealthful.Wearechallengingtounderstandthemolecularandcellularmechanismsofmuscularhomeostasis,regeneration,anddiseases.Thedevelopmentofmushroomcultivarswithsuperiorpropertiessuchashighfruitingbodyproductivity,diseaseresistance,andhumanhealthbenefitswillbeveryimportantforpromotingcommercialproduction.Todevelopthesuperiorcultivarsusingmushroomgeneticresources(e.g.,wildstrainsandcultivars),wearecarryingoutphylogeneticanalysesforexamininggeneticrelatednessbetweenbreedingmaterialsincludingthegeneticresources.Wearealsoisolatingusefulmutantstrainscultivatedmushrooms.(e.g.,albinoandspore-deficientEstimation of genetic relationships among mushroom strains in natural populationsDevelopment of mutant strains for mushroom cultivarsDevelopment of breeding techniques for Himematsutake (Agaricus blazei ＝A. subrufescens )Wearefocusingonskeletalmusclestemcells,satellitecells,whichenabletorobusttheregenerativecapacityofskeletalmuscle.Oursubjectsare;1.Researchonthemechanismofskeletalmuscleregeneration.2.Developmentofthefoodsanddietstopreventmusclediseases.3.Establishmentofthetechnologyforartificialmuscleandmeat.Ourresearchisgoingonthefieldsofagriculturalbiological,andmedicalscienceswiththefinetechniquesofstemcellbiology.strains)forTomohide TAKAYAAssistant Professor, Ph.D.MasakiFUKUDAProfessor,Ph.D.Integrated Bioscience DivisionIntegrated Bioscience DivisionLaboratory of Molecular Cellular BiologyLaboratory of Applied Mushroom Science
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