ACABDBCResveratrol (Res)Cell lysatesRes-bound resinResInputPull down+++++−+Keywords;•Foodimmunology•Dendriticcells•Tcells•IFN-gamma•NKactivityResearchkeywords:Obesity-associateddiseases,Adipogenesis,Adipokines,AdipocytedifferentiationFoodfactors,Foodfunctions,Weareplanningtoexaminetheeffectsoffoodcomponentsanddietaryhabitsonimmunefunctionsandelucidatemolecularmechanismsofimmuneregulation.Moreover,weareaimingfortheinvestigationofunknownimmune-modulatingeffectsofcompoundsderivedfromfoods,andidentificationoffunctionalcomponentstopreventimmune-relateddiseasessuchasinfectiousdisease,cancer,andallergy.Thesestudieswillfoodsexhibitingimmuneregulatingeffects.leadtoapplicationforIdentification of functional compounds and its immune-modulating activities from vegetablestomaintaintheappropriateimmuneInorderfunction,itisconvenientandeffectivetointakeimmune-modulatingfoodsindailylife.WeareplanningtoidentifythefunctionalcompoundsfromvegetablesinShinshu,evaluatetheirbiologicalactivities,andelucidatethemechanismsofimmuneregulation.The effect of dietary restriction on immune functionDietaryrestrictionhasbeenshowntodelayimmunesenescence.However,themechanismsofthegeneexpressionhasnotbeenfullyidentifiedbydietaryrestriction.Wefocusonthealterationofgeneexpressionandrestrictioninvestigatethemechanismsofsuppressionofimmunesenescence.functionalObesityisoneoftheriskfactorsfortype2diabetesandcardiovasculardiseases,andalsodementia.Thus,wefocusonobesitytopreventtheabove-mentioneddiseases.Analysisofmolecularmechanismofanti-obesitytheidentificationofthemoleculartargetsoftheseactivecompounds.compounds,activeDevelopment of a therapeutic agent for obesity and obesity-associated diseases.followingdietaryand12Differentiation to adipocytes3T3-L1 cells are model of adipocytes. We have searched the anti-adipogenesis and anti-obesity compounds using this cells.Furthermore, we have characterized molecular target in adipocytes for active compound against obesity.SachiTANAKAAssociateProfessor,Ph.D.TheresearchinterestsoftheLaboratoryofFoodSciencefocusonthediscoveryanddevelopmentofNutraceuticalsandnovelactivecompoundsthatcanbeusedfordrugsorfunctionalfoods.Inaddition,wechallengetoidentifymoleculartargetsoffoodfactorsthatareeffectiveagainstobesityandits-associateddiseases.Ourlaboratoryaimtodevelopcreativescientistthatcontributestosocietythroughresearchandeducation.TakakazuMITANIAssistantProfessor,Ph.D.Food Science and Biotechnology DivisionFood Science and Biotechnology DivisionLaboratory of FoodImmunologyLaboratory ofFood Function
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