Outlook for research Understanding the nature of stem cells and controlling their fate50応用生物科学科Department of Applied BiologyOutlookforstudentsaftergraduationThespermatogenicpotentialofGScellsisexpectedtofindapplicationnotonlyintreatingmaleinfertility,butalsoinproducingsuperiorlivestock.Inaddition,mGScellsareexpectedtoserveasanothersourceofpluripotentstemcellssuchasiPScells.Inthiscontext,GScellsmightbecalledmultipotentstemcellswiththepotentialtocontributetoawiderangeoffields.Thevalueofthemarketassociatedwithregenerativemedicineisexpectedtogrowto1trillionyenin2020(accordingtostatisticsfromtheMinistryofEconomy,TradeandIndustry).Itismyhopethatourfuturecolleagueswillbeabletoplayaremarkableroleingrowthindustries,includinginregenerativemedicine.RegenerativemedicineusingiPScellsisexpectedtoserveasanovelapproachforcuringdisease.Mylabisfocusingongermlinestem(GS)cells,tissue‐specificstemcellsintestis.AlthoughGScellshavealreadycommittedtogermcelllineage,theyalsohavepluripotencypotentialandoftende‐differentiateintomultipotentGS(mGS)cellsthatpossesspluripotencylikeiPScells.ThegoalofourresearchistounderstandtheuniquenatureofGS/mGScellsandcontroltheirfate.AssociateProfessorSeijiTakashimaAfterreceivingadoctorate(inengineering)fromTokyoInstituteofTechnology,AssociateProfessorTakashimaworkedasaresearchfellowattheUniversityofTokyobeforecomingKyotoUniversityasanassistantprofessor.Hisareasofresearchareregenerativemedicineandstemcellbiology.GScells.Left:MouseGScellsgrowinginvitro.Center:SpermatogenesisinthetestistransplantedwithGScellsexpressinggreenfluorescentprotein(GFP).Right:MouseoffspringproducedfromspermderivedfromGScellsexpressingGFP.TheoffspringalsoexhibitedgreenfluorescenceunderUVlight.ThepluripotencypotentialofGScells.Left:mGScellsde‐differentiated(rejuvenated)fromGScells.mGScellspossesspluripotencylikeiPScells.Right:mGScancontributetotheformationof“chimeramice.”mGS‐derivedtissueinthechimaeramiceexhibitedGFPexpression.Outlook for research Biomaterials that take advantage of the characteristics of biological tissues応用生物科学科Department of Applied BiologyOutlookforstudentsaftergraduationAssociateProfessorJunNegishiAfterreceivingadoctorateinTokyoMedicalandDentalUniversity,AssociateprofessorNegishiworkedasaJSPSpostbeforecomingADEKAasaresearchworker.Hisareasofresearcharebiologicalmaterials..Decellularizedtissueobtainedbyremovingcellsfromlivingtissueconsistsofextracellularmatrix(ECM)andisknowntohavetissue-specificfunctions.Inourlaboratory,wecreateandanalyzedecellularizedtissuefromvarioustissues,clarifythefactorsandcharacteristics,andaimtoapplyittotissueregeneration.Vacuumpressureimpregnationmethod(VPI)usedinmetalprocessingisatechnologythatenablestheefficientintroductionofsolutionsintomaterials.ByapplyingVPItobiomaterialresearch,weaimtodevelopporousmaterialsthatcontaincellsandcompositematerialswithnewproperties.Decellularizedtissueshavesubstance‐specificfunctions,andbybindingtocells,theymaybeabletocreatecomplexbiologicaltissuesandorgansinsideandoutsidethebody.Wealsobelievethatwecandevelopmaterialswithunprecedentedcharacteristicsbymakingfulluseoftechnologiesinvariousfields.Throughresearch,Iwantyoutolearntothink,act,andworkasateam.Ihopethatyouwillmakeuseofyourexperienceinthelaboratoryandplayanactiveroleinvariousfields.Promotion of neurite outgrowth of decellularized tissues.Cell introduction into a porous material by VPI.
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