4Healthy aging for everyone!!Summary of ActivityDiverse physical functions deteriorate with aging. This phenomenon is called senescence. Senescence is associated with various age-associated diseases, such as hypertension, cancer, and dementia. The long-term goal of research in our laboratory is to understand senescence of organism, and age-associated diseases.・Molecular genetic mechanisms of senescence・Anti-aging effects of chemicals, antioxidants, and supplements・Molecular biology of amyloidosis ・Molecular genetics of animal models for hereditary diseases Aging research has the potential not only to achieve a wonderful world where elderly people can enjoy taking an active part in society and enjoy a high quality of life, but also to solve various social problems. Elderly population is expanding worldwide. Accordingly, many countries and local govern-ments adopt a social policy to promote aging research. Postgraduates will play an active role globally as an expert of aging research and contribute to human society. Research subjectOutlook for researchOutlook for students after graduationAging Biology12-month-old Senescence-Accelerated Mouse SAMP1 (top) and normal mice (bottom)OHOHH10H3COH3COCH3CH3CH2Reduced form of coenzyme Q10Electron microscopic image of amy-loid brilsUnderstanding mechanism of gastric cancer development through glycobiologySummary of activityGlycans are regarded as the third biological chains of fundamental biopolymers, followed by nucleic acids and proteins, that closely associated with the biological phenomena such as development, immunity, infection, and cancer. We investi-gate the participation of glycans in causes of various diseases using techniques such as morphology, molecular biology, biochemistry and genetic engineering. Recently, we demonstrated that αGlcNAc protects gastric mucosa against Heli-cobacter pylori (H. pylori) infection and serves as a tumor suppressor for differ-entiated-type gastric adenocarcinoma.・Functional analysis of glycans using genetically engineered mice. ・Role of gastric gland mucin-specific O-glycans in preventing gastric cancer.・Investigation of various helicobacter species in gastric diseases.It may be useful for novel molecular therapies and diagnoses of cancer and inflammation through elucidation of the biological functions of glycans expressed on cell surface or secret-ed from cells under pathological conditions. In addition, anti-microbial drug design exhibiting an anti-microbial effect on H. pylori can be provided. H. pylori resistant to antibiotics become the problem of eradication currently.To be glycobiological specialists such as researchers in universities or public institutes, pri-vate laboratories, or hospitals.Research subjectOutlook for researchOutlook for students after graduationMolecular Pathology（Chief: Prof. Jun Nakayama）They are discussing actively about the correlation between glycans and gastric cancerHe is analyzing a histopathological preparationMouse decient in αGlcNAc
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