36From birthto the end of lifeSummary of ActivityObstetrics and Gynecology (ObGyn) encompasses 4 major academic fields: Obstetrics, Gynecologic On-cology, Reproductive Medicine, and Woman’s healthcare (Fig. 1). ObGyn is the medical field that supports women throughout their lifetime, from birth to the end of life. The uterus and ovaries, which are specific to females, markedly change throughout their lifetime. Pregnancy and delivery are the most dramatic chang-es, in which normal and abnormal conditions may sequentially occur. We want to obtain a clearer under-standing of these changes and diseases specific to women and also perform medical examinations using not only ObGyn, but also, for example, embryology, pathology, and diagnostic imaging.Although medical technologies have rapidly advanced, many issues have yet to be resolved. Among gy-necologic cancers, the morbidity and mortality of endometrial and ovarian cancers are rapidly increasing in Japan. Therefore, the mechanisms underlying endometrial and ovarian carcinogenesis/progression need to be elucidated and new treatment and preventive methods developed based on these mechanisms. Due to advances in perinatal medicine, Japan has become the safest country for pregnancy and delivery. How-ever, the onset mechanisms of hypertensive disorders of pregnancy (HDP) and fetal growth restriction (FGR), which markedly affect perinatal outcomes, remain unclear. Although advances in assisted repro-ductive technologies such as in vitro fertilization and embryo transfer (IVF-ET) have also been achieved, many issues, such as increases in the incidence of chromosomal abnormalities and malformations, have to be overcome in the future.Each of our divisions are actively conducting research to address these issues. ▶Professor: Tanri Shiozawa, M.D., Ph.D.▶Divisions:1. Gynecologic Cancer Group2. Placenta Group3. Reproduction GroupObstetrics and GynecologyProf. Tanri ShiozawaMembers of our DepartmentTherapies for the future eye candidate? "Adrenomedullin"Summary of ActivityThere is a substance in the body that expands blood vessels called adreno-medullin . Recently, there has been the possibility that adrenomedullin improves retinal disease. We focus the influence of adrenomedullin and the substance called RAMP necessary for its action on the eyes. We research whether improve or worsen artificially vascular occlusion or neovessel on the mouse retina using laser device, with poor adrenomedullin or RAMP called knockout mouse.・Study on the influence of adrenomedullin and RAMP on the mouse retina・Study of the retina of mouse artificially induced ocular vessel occlusion and neovascular-ization using laser device・Study of the retina of mice with diabetes mellituAs the aging society progresses, it is expected that eye diseases such as diabetes and vascular occlusion of the retina will increase. There are already various treatments for these diseases, but in the future this adrenomedullin may be one of the treatment optionsAfter graduation, there are continuing to work at our hospital ophthalmologist, or concentrate on clinical practice. Some work at a other hospital or open clinic.Research subjectOutlook for researchOutlook for students after graduationOphthalmology（Chief: Prof. Toshinori Murata）Development specimen of retina of RAMP knockout mouseThe blood vessels are reected in the green A ne blood vessel is very mysteriousA new blood vessel diluted with special liquid. The size changes depending on whether adrenomedullin works or does not work ...Laser device
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