30For the future of patients suering from rare cancersOncology GroupOncology Group(Chief:Masanori Okamoto, Assistant Professor (xed-term))(Chief:Masanori Okamoto, Assistant Professor (xed-term))Orthopaedic SurgerySummary of ActivityCancers in the orthopedic field are often called “rare cancers” because of their low frequency of occurrence and small number of cases. As a result of their rari-ty, the development of diagnostic / therapeutic methods is still lagging, and many patients face unfortunate consequences. Shinshu University is engaged in the development of new therapeutic agents for malignant bone tumors, methods to efficiently deliver anticancer agents o tumors, and new diagnostic criteria for ma-lignant soft tissue tumors. In the clinical field, we are studying bone morphology evaluation using CT images for the prevention of pathological fractures due to bone metastasis and lower limb muscle strength, in addition to the prediction of postoperative function in patients with malignant soft tissue tumors.・Development of new drugs for malignant bone tumors・Analysis of sugar chain-related gene expression in malignant soft tissue tumors ・Evaluation of bone morphology using CT images・Lower limb muscle strength and predictive postoperative function of patients with malig-nant soft tissue tumorsCancer research in the orthopedic field is relatively underdeveloped compared to other areas of oncology, and research themes remain abundant. By establishing new therapeutic drugs and treatment systems, we can still help to “create the future” of patients suffering from can-cer.Because few doctors specialize in orthopedic oncology, learning in this group can provide the potential for you to become an expert in both research and clinical fields. You can aim to become doctors and researchers who can be actively engaged with the world.Research subjectOutlook for researchOutlook for students after graduationGraduate students studying on a daily basis for the development of new therapeutic drugsBone morphology analysis using CT im-ages to predict fracture riskMuscle force measurement using hand held dynamometer/isokinetic dynamome-terUncovering Pathophysiology of Skeletal DiseasesRheumatoid Arthritis & OsteoporosisRheumatoid Arthritis & Osteoporosis（（Chief: Associate Professor・Yukio NakamuraChief: Associate Professor・Yukio Nakamura））Orthopaedic SurgeryResearch SummaryThe number of patients with skeletal diseases has been increasing recently. Many patients suffer from bone destruction or pain due to skeletal diseases, rheumatoid arthritis, and osteoporosis. Consequently, their ADL and QOL is affected. The etiology for most of these diseases remain largely unknown, and effective di-agnosis and treatment are not yet established. We aim to develop a definitive di-agnosis and new methodology in order to identify disease-causing genes and to clarify their functions. In addition, we collaborate internationally with other research teams on various disease-based approaches, including Harvard Medical School and Massachusetts General Hospital. ・To reveal the pathophysiology of osteoporosis and rheumatoid arthritis, and to examine the efficacy of newly-developed drugs ~Rescue 30 million patients in Japan・Identification and functional analyses of disease-causing genes in skeletal diseases・Support for initiatives in regions aiming to extend life expectancy- Prevention and control measures for osteoporosis and locomotive syndrome・To reveal the molecular biology of diseases based on Wnt signaling and sclerostinIdentification of disease-causing genes and a clarification of their functions could enable easy diagnosis and new treatment strategies using blood and urine, there-by bringing hope for patients who suffer from various symptoms in skeletal diseases and offering more treatment options, including surgeries. We hope to share our expertise on bone metabolism and help extend the life expectancy in Shinshu and beyond.By honing your skills and gaining knowledge in both clinical and basic science research, you will be equipped to think logically, communicate effectively, and gain the ability to give elo-quent presentations. In both research and practice, you will be able to develop transferable skills that will help you grow further. Main Research ThemesFuture from ResearchFuture vision after graduationSurgery for Osteoarthritis and Rheumatoid Arthritis April 27 (Mon), 2020The Shinano Mainichi ShimbunJune 1 (Mon), 2020The Shinano Mainichi ShimbunMedical students presenting their research in English
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