信大医学部研究紹介2021(英語版)_プレス品質
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27We Aim to be Number One!General Thoracic SurgeryGeneral Thoracic Surgery((Professor Kimihiro Shimizu, MD, PhDProfessor Kimihiro Shimizu, MD, PhD))SurgerySummary of ActivityThe brand-new Division of General Thoracic Surgery, Department of Surgery was born in August 2019 with an appointment of Professor Kimihiro Shimizu. We treat a variety of thoracic diseases including thoracic malignancies such as a lung cancer, and thymic epithelial tumors (thymoma, thymic cancer); benign diseases such as pneumothorax, and inflammatory lung diseases, and chest trauma. We specifically provide patients with following surgeries aggressively, a “surgery without pain” utilizing a thoracoscope to reduse physical invasiveness and postoperative pain, and a “surgery without shortness of breath” or a segmen-tectomy to preserve nomal lung volume utilizing three-dimensional computed to-mographic (3D-CT) images in patients with small, early-stage lung cancer.(Please visit our Website : https://shinshu-surgery.jp/thoracic) ・To investgate a segmental anatomy of the lungs utilizing 3D-CT images to develop novel surgical strategies to preserve lung volume in patients (Figure)・To integrate lung regeneration technologies and lung preserving surgical strategies to es-tablish safer and oncologically more effective treatment for lung cancer・To investgate a clinical and molecular pathology of lung cancerOur research target is mainly a lung cancer, which has the highest mortality rate among all malignancies. All our efforts in lung cancer research will lead to interests of individual pa-tients and development of future thoracic surgery.After graduation, you should become an international “academic surgeon” who can treat pa-tients with an evidence-based and personalized approaches and publish your achievements based on basic and/or clinical investigations to pursue various questions/interests in clinical practice. Let us aim to become a superb thoracic surgeon who have excellent clinical know ledges with genune skills, and develop together a “number one” thoracic surgery group in Japan and in the world.Research for the futureOur research projectsVision after graduation3D-CT imagesLobectomySegmentectomyRight upperlobectomyUpperUpperlobelobeMiddleMiddlelobelobeLowerLowerlobelobeRight upper lobeS1 segmentectomyAs a Surgical oncologist, we aim to improve treatmentsfor breast and thyroid cancer!Breast and endocrine surgeryBreast and endocrine surgery((Chief: Prof. Ken-ichi ItoChief: Prof. Ken-ichi Ito))SurgerySummary of ActivityWe mainly provide surgical treatment for breast and thyroid cancers. We strive to train “academic surgeons” who can provide treatment based on a scientific understanding of tumors and can devote themselves to basic medical research on tumors as well as clinical work.・Analysis of molecules involved in malignancy and progression of thyroid and breast can-cer・Analysis of the mechanism by which cancer cells acquire resistance to antitumor drugs (drug resistance mechanism)・To be specialists of breast and endocrine surgery.・To be “academic surgeons” who have the creativity they need to thrive on the global stage.Having clinicians engage in research while young prepares them to face the questions and problems they experience in the clinic, let us show the world the clinical and research suc-cesses made at Shinshu!Research subjectOutlook for researchOutlook for students after graduationSurgical specimens ofthyroid cancerMammographic nding ofbreast cancer (arrow)Alteration of protein expressionin breast cancer cellsBreast & endocrine surgeryResearch in our laboratoryExpression of EpCAM/CD44in thyroid cancer cell lines

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