信大医学部研究紹介2021(英語版)_プレス品質
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25Regenerative medicine and treatment of malignancy - bench to bedside -Hepatobiliary pancreatic surgeryHepatobiliary pancreatic surgery((Chief: Assistant Prof. Akira ShimizuChief: Assistant Prof. Akira Shimizu))Surgery (Gastroenterological)Summary of ActivitySurgery has been the 1st choice in the treatment of hepatobiliary pancreatic ma-lignancies.We are aiming to clinical application and pursuing basic research, such as devel-opment of liver organoid and of pancreatic β cell by using regenerative medicine approaches, and establishment of new cancer targeting therapy.・Treatment of postpancreatectomy endocrine dysfunction using pancreatic β cell regenera-tion from non-pancreatic tissues・Analysis of survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib・Analysis of mechanisms of rapid liver regeneration in ALPPS model The technologies of regenerative medicine lead to a novel treatment of organ dysfunction without organ or tissue transplantation after massive organ removal.The new methodology of cancer therapy improves outcomes in treatment of hepatobiliary pancreatic malignancies.Doctors can build careers as researchers in our lab or oversea study program, or as special-ists in hepatobiliary pancreatic surgery in University Hospital, or as board certified surgeons in gastroenterology in the affiliated hospitals.Research subjectOutlook for researchOutlook for students after graduationThree-dimensional insulin-positive cellular aggregate resembled to pancreatic islet (in vitro)Insulin-positive cells in liver in situ induced by gene transfer technique(in vivo)From high quality surgery to gene therapy- New challenge to cancer treatment -Digestive tract surgeryDigestive tract surgery((Chief: Assistant Prof. Yusuke MiyagawaChief: Assistant Prof. Yusuke Miyagawa))Surgery(Gastroenterological)Summary of ActivityThe basis of treatment for esophageal, gastric and colorectal cancer is surgical resection, and we are working on improving quality surgery further pursuing mini-mally invasive, radical and safety.We are also focusing on basic research directly linked to clinical practice. Using the flow cytometer and the latest cell imaging equipment Operetta, we aimed to develop new treatments targeting RAS and BRAF gene mutations of colorectal cancer and RhoA gene mutations of scirrhous gastric cancer.・Establishment of in vitro assay corresponding to individualized treatment of colorectal and gastric cancer・Functional analysis of mutant RHOA in scirrhous gastric cancer・Intraoperative monitoring of recurrent nerve injury of esophageal surgerySince our research method uses a flow cytometer and a cell imaging device (Operetta), functional analysis of many genetic mutations and drug resistance can be efficiently evaluat-ed.Because you can learn a wide range of basic knowledge of cancer and research method us-ing the latest equipment, in the case of getting involved in cancer research and clinical work, the knowledge and technology obtained in this study seems very useful.Research subjectOutlook for researchOutlook for students after graduationGene mutation increases the malignancy of cancer, but at the same time it may be-come a therapeutic targetUsing a ow cytometer (BD FACS Cant II), it is possible to obtain more objective and stable resultsGene mutated cancer cells are mea-sured with a ow cytometerRAS-mutated cells

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