23Challenging for next generation of melanoma treatmentSummary of ActivityOur main projects are the diagnostic method, evaluation method of disease status and new treatment method of malignant melanoma. Because progressed melanoma is difficult to cure, early diagnosis and treatment are very important for patients. Sometimes, it is difficult to distinguish the early melanoma from the benign pigmented nevus. We aim to establish the new diagnosis methods using photographs and a noninvasive method using the nail pieces.Today, immune checkpoint inhibitors and molecular target therapy are often used for the patients suffered from progressed melanoma. We research availability of the combination therapy of ICBs and angiotensin II receptor locker (ARB).・Assessment for melanoma patients using liquid biopsy・Treatment of melanoma by combination of ICBs and ARB.・Imaging diagnosis for melanoma using RGB values・Noninvasive diagnosis by measurement melanin in the nails.Since malignant melanoma is one of the aggressive cancers, once it progress, complete re-mission is difficult. Even using immune checkpoint blockade, objective response rate is up to 30%. We hope that outcomes of our study contribute for improvement both of early diagnosis and treatment of advanced melanoma. You can continue the research in our laboratory or study abroad. Because the our research themes are linked to medical treatment, the knowledge obtained in the research is often useful for clinical practice. There are some members in our laboratory who continue both the research and clinical practice after the graduation.Research subjectOutlook for researchOutlook for students after graduationDermatology（Chief: Prof. Ryuhei Okuyama）Graduate students actively experiment. We can use experimental equipments such as ow cytometry in our laboratory.We accept international students.We instruct politely.Nevus or Melanoma ? Can you diagnose ?Diagnosis & CureSummary of ActivityWe study for developing novel diagnostic and therapeutic methods to solve clinical problems in our department. The main study themes are early diagnosis, differential diagnosis, and pathophysiological analysis by diagnostic imaging, developing novel methods in diagnostic imaging, interventional radiology (IVR), and radiation therapy. Every clinical study is conducted in cooperation with other clinical departments.・Early and differential diagnosis, pathophysiological analysis by diagnostic imaging・Development of novel methods in diagnostic imaging, IVR, and modality・Development of novel curative radiation therapy preserving organ functionsEarly recognition by less-invasive examination; then, expecting complete cure without func-tional loss by less-invasive therapy. Our studies in radiology department will promote bright future in patient-friendly medical care.・Practicing diagnostic imaging, IVR, and radiation therapy as a clinical radiologist in a hos-pital.・Engagement in clinical study and education as a radiologist with a subspeciality in a uni-versity.Research subjectOutlook for researchOutlook for students after graduationRadiology（Prof. Yasunari Fujinaga）Early detection and early diagnosis by diagnostic imagingMinimum invasive therapy by IVR and irradiationAdvanced diagnostic imaging approachingfunctionCurative radiation therapypreserving organ functions
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