信大医学部研究紹介2021(英語版)_プレス品質
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10 Take a leap of faith to reveal the unknownSummary of ActivityToday, number of patient with Kawasaki disease reached 10,000 per a year in Japan. In many cases, the patients acquire their health after the treatment, but some children develop coronary artery aneurysms. Evidences in the study of Ka-wasaki disease suggest genetic factors might be involved in Kawasaki disease. So we investigate genetic background of the patients in order to contribute to the treatment and the diagnosis.・Genetic background of Kawasaki disease・Signal pathway from cytokine receptors・Oncogenesis by retrovirusWe believe our research contributes to human health.Many students after graduation act as researchers in academic fields or companies.Research subjectOutlook for researchOutlook for students after graduationMicrobiology and Immunology(Chief: Prof. Toshikazu Takeshita)MemberEndosomal sorting of cytokine re-ceptor Anti-inammatory effects of immunoglobulin in Kawasaki diseaseHow the immune system is built up and works rightlySummary of ActivityOne of our body’s activities essential to live healthy is the immune system. This system has to work properly, and with too weak immunity we are vulnerable to infections and cancers, while too strong immunity leads to allergies and autoimmune diseases. In order to understand how the immune system works, our laboratory pursues the mechanisms by which to generate various cells in the immune system and to make them work appropriately. These studies will contribute to the prevention and cure of various diseases.・Transcription factors for switching various genes in immune cells on/off in a timely fashion. ・Signal transduction molecules that convey various intracellular signals for the functions of immune cells.Today, in the field of immunology, growing numbers of new therapies are brought forth for cancers and immune-related diseases such as rheumatoid arthritis. Also uncovered recently is the contribution of the immune system to the regulation of good relationship between our health and bacteria living in the gut and skin. Deeper understanding of the immune system will hence provide us with valuable hints on not only improvement of disease diagnosis and therapies, but also better life styles to keep ourselves healthy.By acquiring basic knowledge and gaining practical skills in immunology in our laboratory, graduates are expected to be clinicians who have scientist’s eyes and continuously ask ‘why’ and ‘how’ also in clinics. Research subjectOutlook for researchOutlook for students after graduationMolecular and Cellular Immunology(Chief: Prof. Shinsuke Taki)Ly6CLy6GF4/80CD11cFig.1 Analysis of immune cell populations in the spleen in mice, separated by 4 param-eter owcytometry technique. (yellow: neutrophils, light blue: monocytes, light green: macrophages, pink: dendritic cells) .Fig.2 T lymphocyte subpopulations in the intestinal epithelia in mice made decient in a gene (yellow: TCRαβ T cells, light blue: TCRγδ T cells). Note that TCRαβ T cells are absent in the mutant mice (right). TCRTCRCD8TCRTCRCD8Wild-type miceMutant mice

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