OutlookforstudentsaftergraduationDeveloping the genetic resources of domestic and wild silkworms to make a brand of silkOutlookforstudentsaftergraduationBiopolymers: Gaining an understanding of the function and structure of DNA and enzymes in order to explain their interactions and apply them to biotechnology45Department of Applied BiologyIamcarryingoutresearchintogeneticbreeding,ecdysisandmetamorphosis,andthegeneticrelationshipofthesilkwormtoitsrelative,thegiantsilkworm(naturalsilkworm).MylabcultivatesexcellentstrainsofnaturalsilkwormsinordertoreinvigorateJapan‘ssilkindustry.Thisisdonebysupportingtheraisingofnaturalsilkwormsinsilk‐producingregions.Mygoalistotrainnewtalentthatcancarryonthetraditionofcultivatingandproducingnaturalsilk.Thiswillcreateafuture,wheretheproductionofsilkandotheragriculturalproductsisreinvigoratedthroughacollaborationbetweenagriculture,business,andindustry.Graduatesgoontograduateschoolorworkattextileandfoodcompanies,JA,orlocalcompanies.Someserveasmiddleschoolteachersandpublicofficialsinagriculturalstudies.ProfessorZentaKajiuraProfessorKajiura'sacademiccredentialsareinagriculture,andhisareasofspecializationincludeagricultureandappliedentomology,moleculargenetics.Keywords:DNA,bio‐resources,breedingCocoons and silk from natural silkworms. The cocoons take on a beautiful green color that is unique to Japanese cocoons.Isucceededinbreedingthelargewildsilkworm.Standardwildsilkwormsareshowninthetoprow.Thelargewildsilkwormisshowninthebottomrow.Iusuallyneedmorethan3000cocoonsofthestandardwildsilkwormtoget1kgrawsilk.However,Ionlyneedapproximately2000cocoonsifIusethelargesizewildsilkworm.Iexaminethenatureandstructureofnucleicacids,whichformDNA,carcinogensandactiveoxygen,whichdamagesDNA.MylabisalsoresearchingDNArepairenzymesthatrepairdamagedDNAfromacompletelynewperspectivewiththegoalofclarifyinghowrepairenzymesfinddamagedpartsoftheDNAandapplyingthisknowledgetoresearchintoanti‐carcinogenicdrugs.IfwecouldclarifythefunctionalstructureofDNAandenzymes,webelievethatknowledgecouldbeappliedinthemedicaldomainandeffectivelyusedintheindustrialproductionofbiologicalmaterials.Graduatesareactiveinresearchcentersatpublicresearchinstitutionsandcompaniesaswellasatfoodproductcompaniesandfermentedfoodcompanies,inthemedicaldomain,andatscientificpublishingcompanies.ProfessorToshioShidaProfessorShidajoinedtheFacultyofTextileScienceandTechnologyatShinshuUniversityin1986asaseniorassistantprofessorafterworkingasaresearchassociateattheNagoyaUniversityChemicalInstrumentCenterandasadoctoralresearcheratJohnsHopkinsUniversity.Hetookhiscurrentpositionin2009afterbecominganassociateprofessor.Hisareasofspecializationincludenucleicacidchemistry,proteinengineering,thescienceofbiopolymerproperties,andappliedmicroorganismengineering.Anexplanationofthesubstraterecognitionmechanismofvery‐early‐stageenzymesbeforetheformationoftheenzyme‐substratecomplex,somethingthathadnotpreviouslybeenconsideredforenzymesubstraterecognitionstructure.Farleft:TheenzymehasnotyetfoundthedamagedDNA.Center:TheaminoacidonthesurfaceoftheenzymehasfoundthedamagetotheDNA(intheformofahole).Farright:TheenzymeisattemptingtorepairthedamagedDNA.Outlook for research Outlook for research Department of Applied BiologyDepartment of Applied BiologyInitial complex formation stageAP endonuclease AP-DNA +AP endonucleaseAP site 『Recognizer: Tryptophan residue』AP site search tentaclesUltimate enzyme-substrate complexE. coliP. aeruginosaD strainR strainSEM Image: Membrane filter pore size 0.6 µm
元のページ ../index.html#46