Byincorporatinglivingorganismsintoman‐madesystemssuchasmachineparts,Iamworkingtodevelopnewtechnologiesthatdifferfromexistingmachinesystems.Forexample,Iamcurrentlyattemptingtocreatebio‐hybridrobotswithself‐assemblyandself‐repairfunctionsthatdonotrequireelectricityorfossilfuelsbyincorporatingmusclesintosystemsinsteadofmotors.Atthesametime,Iamalsodevelopingtechnologiesforoperatingcellsviamagneticfieldsandsystemsforfabricatingbiologicaltissuethatcanbetransplantedfromcells.Modernsocietyisdependentonfossilfuels,butexpertsonlyexpectthoseresourcestolastforabout150moreyears.Ifmusclescouldbeusedtopowerrobots,ourenergyproblemscouldberesolved.Additionally,theabilitytogrowthree‐dimensionaltissuethatcanbetransplantedfromiPScells,whichareabletodifferentiateintoallcelltypes,wouldcontributegreatlytothedevelopmentofregenerativemedicine.Ihavenotmentoredanygraduatesyetinmycurrentposition,butgraduateswhomImentoredinmypreviouspositionhavebeenemployedbymedicalequipmentandprecisionequipmentmanufacturers.AssociateProfessorYoshitakeAkiyamaAftercompletingagraduateprogramatTokyoUniversityofAgricultureandTechnology,AssociateProfessorAkiyamaworkedatJEOLLtd.,atTokyoUniversityofAgricultureandTechnologyasaspeciallyappointedassistantprofessor,andatOsakaUniversityasaseniorassistantprofessorbeforecomingtohiscurrentpositionin2014.Hisfieldsofspecializationincludebiotechnology,micromachining,regenerativemedicine,andtheintegrationofthesame.A micro‐robot walks autonomously (left) while a micro pinset movesthrough its environment (right), both using muscle tissue.An illustration (left) and overview (right) of how tissue could befabricated from cells via magnetic fieldsCreating new bio‐hybrid technologies for applications ranging from micro‐robots to regenerative medicineFrom neurotrauma to neuroregenerationRepetitivebrainconcussioninplayingfootball,judo,andrugbyinducescognitivedysfunctionssuchasmemorydysfunction.Thebrainbecomesvulnerableandsensitivetostimulibyrepeatedheadcollisions,resultingindecreasingthethresholdofbraininjury.Therapiddeformationofbraintissueistypicallycausedbyheadimpactintrafficaccidentsbecausetheinertiaforceisappliedtothebraintissuebysuddenaccelerationanddecelerationofthehead.Therebyneuronsarestretched,andaxons,whichplayaroleinneurotransmission,areinjuredanddisrupted.Wehavedevelopedthecriteriaofaxonalinjurythroughtheimpactloadingexperimentofbrainneuronalcellstobetterunderstandthemechanismofaxonalinjuryinrepetitivebrainconcussion.Studentscanlearnthelogicalthinking,theproblemsolvingabilityandcommunicationskillsthroughstudyingautonomously.Theyalsocanenhanceaconnectionwithcollegersthroughthelifeoflaboratory.AssociateProfessorHiromichiNakadateAssociateProfessorNakadatetookhiscurrentpositionin2018afterworkingasanassistantprofessoratTokyoMetropolitanUniversity.Hisresearchfieldisbraininjurybiomechanics.Cell stretching device for reproducing the brain deformation in head impactThemeasuringaccuratelytheconditionandbehaviorofbraincellsexposedtomechanicalstressallowsustopredictbrainneurologicaldamagethatcannotbedetectedthediagnosticimagingsuchasCTandMRIbycomputationalsimulation,andthisstudyleadstoanoveldiagnosissystemandestablishingsafetycriteriaofautomobile.Axons elongated randomly by normal culture (left) and Axons oriented straight by controlling adherence property of culturing surface (right)26Department of Machinery and RoboticsBioengineeringDepartment of Machinery and RoboticsBioengineeringOutlook for researchOutlook for students after graduationOutlook for researchOutlook for students after graduation
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