信大医学部医学科研究紹介2020(英語版)
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25Surgical treatment for digestive tract cancer and liver transplantation for Intractable liver diseaseGastroenterological,Gastroenterological,hepato-biliary-pancreatic,hepato-biliary-pancreatic,transplantation and pediatrictransplantation and pediatricSurgerySummary of ActivityIn Department of Surgery, Division of gastroenterological, hepato-biliary-pancreatic, transplantation and pediatric, we conduct clinical prac-tice and research into three groups of hepatobiliary pancreatic group, digestive tract group, transplant and pediatric surgery group.The main target of treatment are gastroenterological malignancies such as liver cancer, pancreas cancer, biliary tract cancer, esophageal cancer, gastric cancer and colorectal cancer. In addition to surgical treatment, comprehensive treatment such as diagnosis and chemother-apy is the corresponding area.In transplantation and pediatric group, living donor liver transplantation and cadaveric donor liver transplantation for end-stage liver disease and some liver-related metabolic disease have been carried out with low mortality rate.Clinical research and basic research on digestive tract cancer, transplantation, regenerative medicine are also conducted. Please see the pages of each groups for details of research contents.Clinical Subject・Improvement of operative results in hepato-biliary pancreqatic malignancy.・Combination therapy of extended surgical operation and anti-cancer drugs against advanced colorectal and gastric cancer.・Less invasive thoracoscopic/laparoscopic surgery for esophageal cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, pancreatic tumor and other GI malignancies.・Living donar liver transplantation and caderveric donor liver transplantation for chronic liver disease, acute liver failure and metabolic disorder.・Surgical treatment for various pediatric disease.▶Divisions:1. Hepato-biliary pancreatic surgery group2. Digestive tract surgery group3. Transplantation and pediatric surgery groupRegenerative medicine and treatment of malignancy - bench to bedside -Hepatobiliary pancreatic surgeryHepatobiliary pancreatic surgery((Chief: Assistant Prof. Akira ShimizuChief: Assistant Prof. Akira Shimizu))Surgery (Gastroenterological)Summary of ActivitySurgery has been the 1st choice in the treatment of hepatobiliary pancreatic ma-lignancies.We are aiming to clinical application and pursuing basic research, such as devel-opment of liver organoid and of pancreatic β cell by using regenerative medicine approaches, and establishment of new cancer targeting therapy.・Treatment of postpancreatectomy endocrine dysfunction using pancreatic β cell regenera-tion from non-pancreatic tissues・Analysis of survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib・Analysis of mechanisms of rapid liver regeneration in ALPPS model The technologies of regenerative medicine lead to a novel treatment of organ dysfunction without organ or tissue transplantation after massive organ removal.The new methodology of cancer therapy improves outcomes in treatment of hepatobiliary pancreatic malignancies.Doctors can build careers as researchers in our lab or oversea study program, or as special-ists in hepatobiliary pancreatic surgery in University Hospital, or as board certified surgeons in gastroenterology in the affiliated hospitals.Research subjectOutlook for researchOutlook for students after graduationThree-dimensional insulin-positive cellular aggregate resembled to pancreatic islet (in vitro)Insulin-positive cells in liver in situ induced by gene transfer technique(in vivo)

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