Laboratory of Molecular Cellular BiologyTomohide TAKAYAAssistant Professor, Ph.D.•Stem cell biology•Skeletal muscle•Myogenic differentiation•Regenerative medicine•Transcription factorMuscledistinguishesanimals.Wecanmoveaswewantbymusclefunctions.Higheranimalshavethreetypesofmuscles;cardiac,smooth,andskeletalmuscles.Ourmovementscanberealizedbycooperationofthreemuscles.Thesemusclecellsareverysimilar,inthesameway,quitedifferent.Oneofourinterestsisthemechanismwhichenablesmusclediversity.Forhealthylongevity,allmusclesshouldbemaintainedhealthful.Wearechallengingtounderstandthemolecularandcellularmechanismsofmuscularhomeostasis,regeneration,anddiseases.ABCDABCImmunostainingofskeletalmusclestemcellsduringmyogenicdifferentiationinculture.Bioinformaticanalysisofthegenome-wideDNA-bindingsitesofmyogenictranscriptionfactors.Integrated Bioscience DivisionWearefocusingonskeletalmusclestemcells,satellitecells,whichenabletorobusttheregenerativecapacityofskeletalmuscle.Oursubjectsare;1.Researchonthemechanismofskeletalmuscleregeneration.2.Developmentofthefoodsanddietstopreventmusclediseases.3.Establishmentofthetechnologyforartificialmuscleandmeat.Ourresearchisgoingonthefieldsofagriculturalbiological,andmedicalscienceswiththefinetechniquesofstemcellbiology.Day 0Day 1Day 2Day 3Laboratory of Applied Mushroom ScienceMasakiFUKUDAProfessor,Ph.D.•Mushroom genetics•Mushroom breeding•Mushroom phylogeny•Genetic resources•Mutant strainsThedevelopmentofmushroomcultivarswithsuperiorpropertiessuchashighfruitingbodyproductivity,diseaseresistance,andhumanhealthbenefitswillbeveryimportantforpromotingcommercialproduction.Todevelopthesuperiorcultivarsusingmushroomgeneticresources(e.g.,wildstrainsandcultivars),wearecarryingoutphylogeneticanalysesforexamininggeneticrelatednessbetweenbreedingmaterialsincludingthegeneticresources.Wearealsoisolatingusefulmutantstrains(e.g.,albinoandspore-deficientstrains)forcultivatedmushrooms.Estimation of genetic relationships among mushroom strains in natural populationsCDAfter collecting mushroom genetic resources, isolating mycelial cultures, and preserving mushroom strains, we are developing superior cultivars using the strains.A: Students are performing mushroom genetic studies in the laboratory. B: Protoplasts from Pleurotus ostreatusC: DNA fingerprints for Flammulina velutipesIntegrated Bioscience DivisionDevelopment of mutant strains for mushroom cultivarsDevelopment of breeding techniques for Himematsutake (Agaricus blazei ＝A. subrufescens )自動収穫機によって根が均一に切断されたホウレンソウ2. Mycelium isolation culture1. Collection of mushroom genetic resources5. Selection of superior cultivars3. Preservation of mushroom genetic resources4. Evaluation ofgenetic resourcesABC4
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