Laboratory ofFood FunctionTakakazuMITANIAssistantProfessor,Ph.D.Researchkeywords:Obesity-associateddiseases,Adipogenesis,Adipokines,AdipocytedifferentiationFoodfactors,Foodfunctions,TheresearchinterestsoftheLaboratoryofFoodSciencefocusonthediscoveryanddevelopmentofNutraceuticalsandnovelactivecompoundsthatcanbeusedfordrugsorfunctionalfoods.Inaddition,wechallengetoidentifymoleculartargetsoffoodfactorsthatareeffectiveagainstobesityandits-associateddiseases.Ourlaboratoryaimtodevelopcreativescientistthatcontributestosocietythroughresearchandeducation.Obesityisoneoftheriskfactorsfortype2diabetesandcardiovasculardiseases,andalsodementia.Thus,wefocusonobesitytopreventtheabove-mentioneddiseases.3T3-L1 cells are model of adipocytes. We have searched the anti-adipogenesis and anti-obesity compounds using this cells.Furthermore, we have characterized molecular target in adipocytes for active compound against obesity.Food Science and Biotechnology DivisionAnalysisofmolecularmechanismofanti-obesityactivecompounds,andtheidentificationofthemoleculartargetsoftheseactivecompounds.Development of a therapeutic agent for obesity and obesity-associated diseases.Differentiation to adipocytesCell lysatesRes-bound resinResInputPull down−++++++Resveratrol (Res)12Laboratory of FoodImmunologySachiTANAKAAssociateProfessor,Ph.D.Keywords;•Foodimmunology•Dendriticcells•Tcells•IFN-gamma•NKactivityWeareplanningtoexaminetheeffectsoffoodcomponentsanddietaryhabitsonimmunefunctionsandelucidatemolecularmechanismsofimmuneregulation.Moreover,weareaimingfortheinvestigationofunknownimmune-modulatingeffectsofcompoundsderivedfromfoods,andidentificationoffunctionalcomponentstopreventimmune-relateddiseasessuchasinfectiousdisease,cancer,andallergy.Thesestudieswillleadtoapplicationforfunctionalfoodsexhibitingimmuneregulatingeffects.Identification of functional compounds and its immune-modulating activities from vegetablesInordertomaintaintheappropriateimmunefunction,itisconvenientandeffectivetointakeimmune-modulatingfoodsindailylife.WeareplanningtoidentifythefunctionalcompoundsfromvegetablesinShinshu,evaluatetheirbiologicalactivities,andelucidatethemechanismsofimmuneregulation.ABCDABCFood Science and Biotechnology DivisionThe effect of dietary restriction on immune functionDietaryrestrictionhasbeenshowntodelayimmunesenescence.However,themechanismsofthegeneexpressionhasnotbeenfullyidentifiedbydietaryrestriction.Wefocusonthealterationofgeneexpressionfollowingdietaryrestrictionandinvestigatethemechanismsofsuppressionofimmunesenescence.
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