Laboratory of Food Molecular EngineeringKozoNAKAMURAAssociateProfessor,Ph.D.FunctionalFoods,CholineEstersPeptides,PolyphenolsAntihypertensiveFoodsTheLaboratoryofFoodMolecularEngineeringconductsresearchonutilization,quantificationandisolatedpurificationoffunctionalmoleculesinfoodandfoodresources.Cholineesters,peptidesandpolyphenolsaremaintargetcompounds,andwefocusontheireffectsonthecardiovascularsystemandnervoussystem.FoodproductsfromtheShinshuregionsuchas“fermentedfoods”,“buckwheat“and“medicinalplants”arerichinthesefunctionalmolecules.Recently,wefoundthat“eggplant”wasrichinacetylcholineandhadanantihypertensiveeffectinspontaneouslyhypertensiverat.Foodmolecularengineeringmakesthefoodfunctionalitiesmoreeffectiveandincreasestheutilityvalue.▪LacticfermentedbuckwheatThisfermentedfoodcontainsabundantacetylcholineandlactoylcholineandshoweddecreaseofsystolicbloodpressureofhumansubjects.Choline esters are NEWfood functional factors. We are the first to isolate the natural LaCh. Food Science and Biotechnology Division▪FoodfunctionalityofeggplantEggplantcontainsmuchmoreabundantacetylcholinethantheothervegetablesandisexpectedtohaveantihypertensiveandanti-stresseffects.N+OOAcetylcholine(AcCh)N+OOPropionylcholine(PrCh)N+OOButylylcholine(BuCh)N+OOOHLactoylcholine(LaCh)AcCh is a typical choline esters and neurotransmitter of mammals. The content in eggplant is 3 mg/100g F.W in average.OON+AcCh9Laboratory of Synthetic Natural Products ChemistryHidefumiMAKABEProfessor,Ph.D.Keywords:organicsynthesis,naturalproducts,bioactivecompounds,Structure-activityrelationships,organometallicsTheresearchinourgroupfocusesaroundthechemistryofbiologicallyactivenaturalproducts:synthesis,structure-activityrelationships,biosynthesis,biosyntheticinhibitors,isolationandstructureelucidation.Developmentofnovelchemicalreactionusingorganometallicsisalsostudied.Synthesis of biologically active polyphenolsWehavegreatinterestinpolyphenolsbecauseoftheirpotentbiologicalactivities.Thus,wehavesynthesizedthesemoleculesforanalysisoftheirstructure-activityrelationships.ABCDABCAntitumor activity of procyanidin B3 and prodelphinidin B3 against human PC-3 prostate cancer cell lines. Prodelphinidin B3 which has pyrogallol moiety (red colored) possesses significant activity.NMR is essential tool to elucidate the structure of organic compounds.Food Science and Biotechnology DivisionSynthesis of natural products using organometallicsStereoselective aminopalladation and oxypalladation are very important approaches for the synthesis of various natural products which contain N-and O-hetero-alicycles. We accomplished the synthesis of natural products using Pd(II)-catalyzed stereoselective cyclization.Not activeactive（写真一枚or複数枚組み合わせ）Structural elucidation using NMR
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