Laboratory of Food Microbial EngineeringMasato IKEDAProfessor, Ph.D. Keywords: Applied microbiology, Metabolic engineeringCorynebacterium glutamicum,Fatty acids and their derivatives, VitaminsFermentationtechnologyfortheproductionofusefulsubstancesisoneofthefieldsinwhichJapanhasledtheworld.WearedevelopingtheindustrialmicroorganismCorynebacteriumglutamicumasaproductionplatformnotonlyforwater-solublemetabolites,suchasaminoacidsandnucleicacids,butalsoforwater-insolublelipids.Ourcurrentinterestsinvolvemicrobialproductionofusefulfattyacidsandvitaminsderivedtherefrom(e.g.,biotin).Biotinavailableintheworldisexclusivelymanufacturedfrompetroleum,anditsmicrobialproductionhasnotbeenestablished.Weareworkingondevelopingworld’sfirstbiotechnologywithemphasizingoriginalityanduniqueidea.Food Science and Biotechnology DivisionDevelopment of production base of fatty acids and sulfur-containing fatty acid derivativesDevelopment ofenvironment-friendly process independent of fossil fuelDevelopment of innovativestrain engineering methodology with originality and practicalityInourLab,thelatesttechnologiesandBigDataoncells(genomeinformation,in-silicometabolicmaps,etc.)areusedtocreatesuperiorproductionstrains.Corynebacteriumglutamicumisamicroorganismthatnaturallyrequiresbiotin,animportantvitaminforourhealth.Byusinggenesfromotherbacterialspecies,wedevelopedtheworld’sfirstbiotin-nonrequiringstrainofC.glutamicum,whichproducesbiotinintheculturemedium(leftmostphoto).Wealsofoundthatonlyonemutationenablesthewild-typestraintoproducefattyacids(rightmost).Wild typeFatty acid producerBiotin producer7Laboratory ofMolecular BiologyKikuoSENProfessor,Ph.D.Microbial pesticides,Mushrooms,Production of useful substances,Signal transduction,Genetic engineeringWe are aiming to create an affluent and sustainable society by utilizing useful microbial resources. As the research subject, both of prokaryotic and eukaryotic microorganisms are studied by methods of molecular biology and genetic engineering.Development of microbial pesticide Bacillus thuringiensisACFruit bodies of basidiomycetous mushrooms, Schizophyllum commune (left) and Coprinopsis cinerea (right), on agar mediaElucidation of the mechanism of fruit body formation of basidiomycetous mushroomsA photomicrograph of Bacillus thuringiensisproducing spores and insecticidal crystalsCrystalSporeFood Science and Biotechnology Division
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