信大医学部医学科研究紹介2019（英語版）

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43To Study Research Philosophy and Techniques on International LevelSummary of ActivityTo conduct the innovation of medical and health sciences research, we have es-tablished the department with donation of BOURBON Co. and Aizawa Hospital and financial support of Rubycon Ltd, and Skinos Ltd, NEC Solution Innovators, Ltd. Please access the homepage to our department to get more detail Information: http://www.shinshu-u.ac.jp/faculty/medicine/chair/medicalhealth/index.html・ Human clinical and animal experimental researches to evaluate their absorption ability of foods in the small intestines and their-related gut innate immunology・ Human clinical research to establish the method calculated for the lymph flow rate through thoracic duct in healthy subjects・ Human clinical research to establish new concept of CO2 gas exchange mechanisms in lung ・ Development new medical machines and sensors to measure palmer or skin perspiration and then their clinical application・ Offer public lecture for subjects to promote health and writing books concerning gut lymph and immunology or the logic of life for citizensWe have attempted to develop new techniques of medical research combined with physio-logical and clinical approach, and molecular and genetic ones.We hope to help their research activity in future to get their pos-doc position in our collab-orated laboratory in the world, for example Prof. Cao, Kalolinska Institute, Sweden; Prof. VanHelden, The University of Newcastle, Australia;Prof. Schmid-Schoenbein, UCSD, USA; Prof. Jacobowitz, NIH, USAResearch subjectOutlook for researchOutlook for students after graduationInnovation of Medical and Health Sciences Research（Chief: Prof. Mikito Kawamata, Prof. Toshio Ohhashi）The memorial meeting of our department, 2015Our recent published bookA Breakthrough Drug Development for Refractory DiseasesSummary of ActivityOur research is funded by Kissei Pharmaceutical Co. Ltd. We strive to create new drugs from seeds originated in Shinshu University, develop and deliver them to patients in order to improve their quality of life(QOL). We specialize in areas with high unmet medical needs, and do our research using any technologies available. Exit strategies of our research include university-industry joint researches, intro-duction of drug seeds to the pharmaceutical companies, translational research-es, and foundation of the start-up companies.・ A cutting-edge drug discovery for a lysosome disease using animal models.・ The discovery of chaperons for the treatment of a rare genetic disorder. ・ Novel CAR-T development for the refractory hematological cancer.We achieve the development of novel drugs for the patients who suffer from untreatable diseases, for which no drug is developed nor planned due to a small number of patients. Consequently, we can improve the QOL of patients, and contribute to advances in medical sciences.Those who join our research team will gain valuable experiences for their future drug discov-ery researches, translational researches and /or clinical trials. Research subjectOutlook for researchOutlook for students after graduationDrug Discovery Science（Chief: Specially Appointed Prof. Hideki Ohnota）Our research teamP2 biohazard laboratoryAn educational lecture