信大医学部医学科研究紹介2019（英語版）

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36Therapies for the future eye candidate? "Adrenomedullin"Summary of ActivityThere is a substance in the body that expands blood vessels called adreno-medullin . Recently, there has been the possibility that adrenomedullin improves retinal disease. We focus the influence of adrenomedullin and the substance called RAMP necessary for its action on the eyes. We research whether improve or worsen artificially vascular occlusion or neovessel on the mouse retina using laser device, with poor adrenomedullin or RAMP called knockout mouse.・Study on the influence of adrenomedullin and RAMP on the mouse retina・ Study of the retina of mouse artificially induced ocular vessel occlusion and neovascular-ization using laser device・Study of the retina of mice with diabetes mellituAs the aging society progresses, it is expected that eye diseases such as diabetes and vascular occlusion of the retina will increase. There are already various treatments for these diseases, but in the future this adrenomedullin may be one of the treatment optionsAfter graduation, there are continuing to work at our hospital ophthalmologist, or concentrate on clinical practice. Some work at a other hospital or open clinic.Research subjectOutlook for researchOutlook for students after graduationOphthalmology（Chief: Prof. Toshinori Murata）Development specimen of retina of RAMP knockout mouseA new blood vessel diluted with special liquid. The size changes depending on whether adrenomedullin works or does not work ...Laser deviceand developing a new therapySummary of ActivityHearing loss affects about over 300 million people worldwide and is the most common sensory deficit. Genetic factors account for at least 60% of child-hood sensorineural hearing loss (SNHL). Recent advances in next generation sequencing (NGS) tecqnology have made the sequencing of many causative genes simultaneously possible. We address genetic analysis in hearing loss for investigating novel causative genes, molecular mechanisms and new therapeutic options. ・ Comprehensive genetic analysis using NGS technology・ Whole genome or exome sequencing for novel gene discovery・ Developing disease specific iPS cell line for pathological analysisThe pathogenic mechanism of SNHL remains unclear, because something happens in the invisible small inner ear. Now, in patients with SNHL a genetic etiology can be identified us-ing NGS. We will move on to the next step, which creating a new therapy as genetic-cause specific treatment. You must consider what cause hearing loss, when you could chose a therapeutic option for the patient. Research for hearing loss is now getting wider and deeper, so you can join us for the challenges. Research subjectOutlook for researchOutlook for students after graduationOtorhinolaryngology（Chief: Prof. Shin-ichi Usami）Genetic analysis instruments, including NGS are avail-able. Cell culture experiment for the patho-logical analysis.