信大医学部医学科研究紹介2019(英語版)
32/48

30from rare cancers(Chief: Munehisa Kito, Clinical Assistant)Orthopaedic SurgerySummary of ActivityCancers in the orthopedic field are often called “rare cancers” because of their low frequency of occurrence and small number of cases. As a result of their rari-ty, the development of diagnostic / therapeutic methods is still lagging, and many patients face unfortunate consequences. Shinshu University is engaged in the development of new therapeutic agents for malignant bone tumors, methods to efficiently deliver anticancer agents o tumors, and new diagnostic criteria for ma-lignant soft tissue tumors. In the clinical field, we are studying bone morphology evaluation using CT images for the prevention of pathological fractures due to bone metastasis and lower limb muscle strength, in addition to the prediction of postoperative function in patients with malignant soft tissue tumors.・Development of new drugs for malignant bone tumors・Analysis of sugar chain-related gene expression in malignant soft tissue tumors ・Evaluation of bone morphology using CT images・ Lower limb muscle strength and predictive postoperative function of patients with malig-nant soft tissue tumorsCancer research in the orthopedic field is relatively underdeveloped compared to other areas of oncology, and research themes remain abundant. By establishing new therapeutic drugs and treatment systems, we can still help to “create the future” of patients suffering from can-cer.Because few doctors specialize in orthopedic oncology, learning in this group can provide the potential for you to become an expert in both research and clinical fields. You can aim to become doctors and researchers who can be actively engaged with the world.Research subjectOutlook for researchOutlook for students after graduationGraduate students studying on a daily basis for the development of new therapeutic drugsBone morphology analysis using CT im-ages to predict fracture riskMuscle force measurement using hand held dynamometer/isokinetic dynamome-terUncovering the mysteries of skeletal diseases with genes(Chief: Senior Assistant Prof. Yukio Nakamura)Orthopaedic SurgeryResearch SummaryMany patients suffer from bone destruction or pain due to congenital skeletal diseases, rheu-matoid arthritis, and osteoporosis. However, the etiology for most of these diseases remain largely unknown, and effective diagnosis and treatment are not yet established. We aim to develop a definitive diagnosis and new methodology in order to identify disease-causing genes and to clarify their functions. In addition, we collaborate internationally with other re-search teams on various disease-based approaches, including Harvard Medical School. ・Identification and functional analyses of disease-causing genes in congenital skeletal diseases・Support for initiatives in regions aiming to extend life expectancy ~Prevention and control measures for osteoporosis and locomotive syndrome~・To reveal the pathophysiology of osteoporosis and rheumatoid arthritis, and to examine the efficacy of newly-developed drugs・To reveal the molecular biology of diseases based on Wnt signaling and sclerostinIdentification of disease-causing genes and a clarification of their functions could enable easy diagnosis and new treatment strategies using blood and urine, thereby bringing hope for patients who suffer from various symptoms in skeletal diseases and offering more treat-ment options, including surgeries. We hope to share our expertise on bone metabolism and help extend the life expectancy in Shinshu and beyond.By honing your skills and gaining knowledge in both clinical and basic science research, you will be equipped to think logically, communicate effectively, and gain the ability to give elo-quent presentations. In both research and practice, you will be able to develop transferable skills that will help you grow further. Main Research ThemesFuture from ResearchFuture vision after graduationZebrafish have skeleton; thus, they are a suitable model to study skeletal genes(diameter, 0.5-1mm)

元のページ  ../index.html#32

このブックを見る