Laboratory of Molecular Cellular Biology Tomohide TAKAYA Assistant Professor, Ph.D. - Stem cell biology - Skeletal muscle - Myogenic differentiation - Regenerative medicine - Transcription factor Muscle distinguishes animals. We can move as we want by muscle functions. Higher animals have three types of muscles; cardiac, smooth, and skeletal muscles. Our movements can be realized by cooperation of three muscles. These muscle cells are very similar, in the same way, quite different. One of our interests is the mechanism which enables muscle diversity. For healthy longevity, all muscles should be maintained healthful. We are challenging to understand the molecular and cellular mechanisms of musclular homeostasis, regeneration, and diseases. A B C D A B C Immunostaining of skeletal muscle stem cells during myogenic differentiation in culture. Bioinformatic analysis of the genome-wide DNA-binding sites of myogenic transcription factors. Integrated Bioscience Division We are focusing on skeletal muscle stem cells, satellite cells, which enable robust regenerative capacity of skeletal muscle. Our subjects are; 1.Research of the mechanism of skeletal muscle regeneration. 2.Development of the foods and diets to prevent muscle diseases. 3.Establishment of the technology for artificial muscle and meat. Our research is going on the fields of agricultural biological, and medical sciences with the fine techniques of stem cell biology. Day 0 Day 1 Day 2 Day 3 Laboratory of Applied Mushroom Science Masaki FUKUDA Professor, Ph.D. Mushroom genetics Mushroom breeding Mushroom phylogeny Genetic resources Mutant strains The development of mushroom cultivars with superior properties such as high fruiting body productivity, disease resistance, and human health benefits will be very important for promoting commercial production. To develop the superior cultivars using mushroom genetic resources (e.g., wild strains and cultivars), we are carrying out phylogenetic analyses for examining genetic relatedness between breeding materials including the genetic resources. We are also isolating useful mutant strains (e.g., albino and spore-deficient strains) for cultivated mushrooms. Estimation of genetic relationships among mushroom strains in natural populations C D After collecting mushroom genetic resources, isolating mycelial cultures, and preserving mushroom strains, we are developing superior cultivars using the strains. A: Students are performing mushroom genetic studies in the Laboratory. B: Protoplasts from Pleurotus ostreatus C: DNA fingerprints for Flammulina velutipes Integrated Bioscience Division Development of mutant strains for mushroom cultivars Development of breeding techniques for Himematsutake (Agaricus blazei ＝A. subrufescens ) 自動収穫機によって根が均一に切断されたホウレンソウ 2. Mycelium isolation culture 1. Collection of mushroom genetic resources 5. Selection of superior cultivars 3. Preservation of mushroom genetic resources 4. Evaluation of genetic resources A B C 4
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