農学部研究紹介英語版2019-2020
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Laboratory of Applied and Molecular Microbiology Takeshi HOSAKA Associate Professor, Ph.D. Actinomycetes, Antibiotic, Secondary metabolism, Ribosome engineering, Antibiotic hormesis Actinomycetes produce abundant amounts of numerous bioactive metabolites, including antitumor agents, immunosuppressants and antibiotics in particular. Whole-genome sequencing studies of actinomycete strains have shown that each species could produce many more secondary metabolites than were expected. This indicates that the vast majority of secondary metabolites remain unexpressed or barely expressed under standard laboratory conditions. Thus, there is considerable interest in exploring practical means to induce this genetic potential in actinomycetes, which could result in isolation of novel bioactive secondary metabolites. Our laboratory aims to understand the molecular mechanisms activating secondary metabolism and to establish effective methods for developing cryptic gene clusters for secondary metabolic pathways in microorganisms. Molecular analysis of the activation mechanism for secondary metabolism of microorganisms and its application to the development of new strategies for exploring useful biologically active compounds. Production of useful biologically active compounds by actinomycete strains. Actinomycetes produce abundant amounts of numerous bioactive secondary metabolites. Biotechnology Division Analysis of the molecular mechanisms of antibiotic hormesis, toward understanding the truth about antibiotics, and its applications for antibiotic discovery. Actinomycetes Wild-type strain Mutant strain 31 Laboratory of Animal Physiology Shinichi YONEKURA Associate Professor, Ph.D. /Skeletal muscle /Mammary gland /Neurodegenerative disease /Cell biology /Molecular Biology Current research in our lab focuses on understanding growth and development at the cellular level to identify methods to improve efficiency of animal production. Regarding the animal production, currently there are two major focuses in the laboratory. The first is to understand the molecular mechanism of skeletal muscle development. The second focus in the laboratory is to determine the molecular mechanism of mammary gland development. In addition, we are investigating the molecular mechanism of neurodegenerative disease and trying to find out the prevention factors for these diseases. Molecular mechanisms of skeletal muscle development A B C D A B C Mice and Drosophila as a model for studying about the molecular mechanism of mammary gland development and neurodegeneration. Tissue culture experiments are necessary for understanding at molecular basis. Right picture indicates myotube formation after myogenic stimuli. Biotechnology Division Molecular mechanisms of mammary gland development Molecular mechanisms of neurodegenerative disease and explore the prevention factors Mammary gland Neuron (写真一枚or複数枚組み合わせ) 活性あり Day 0 Day 4 Tissue culture experiment in vivo experiment (Mice, Drosophila)

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