Laboratory of Food Function Takakazu MITANI Assistant Professor, Ph.D. Research keywords: Obesity-associated diseases, Adipogenesis, Adipokines, Adipocyte differentiation Food factors, Food functions, The research interests of the Laboratory of Food Science focus on the discovery and development of Nutraceuticals and novel active compounds that can be used for drugs or functional foods. In addition, we challenge to identify molecular targets of food factors that are effective against obesity and its-associated diseases. Our laboratory aim to develop creative scientist that contributes to society through research and education. Obesity is one of the risk factors for type 2 diabetes and cardiovascular diseases, but also dementia. Thus, we focus on obesity to prevent the above-mentioned diseases. 3T3-L1 cells are model of adipocytes. We have searched the anti-adipogenesis and anti-obesity compounds using this cells. Furthermore, we have characterized molecular target in adipocytes for active compound against obesity. Food Science and Biotechnology Division Analysis of molecular mechanism of anti-obesity active compounds, and Identification of the molecular targets of these active compounds. Development of a therapeutic agent for obesity and obesity-associated diseases. Differentiation to adipocytes Cell lysates Res-bound resin Res Input Pull down − + + + + + + Resveratrol (Res) 12 Laboratory of Food Immunology Sachi TANAKA Associate Professor, Ph.D. Keywords; Food immunology Dendritic cells T cells IFN-gamma NK activity We are planning to examine the effects of food components and dietary habits on immune functions and elucidate molecular mechanisms of immune regulation. Moreover, we are aiming for the investigation of unknown immune-modulating effects of compounds derived from foods, and identification of functional components to prevent immune-related diseases such as infectious disease, cancer, and allergy. These studies will lead to application for functional foods exhibiting immune regulating effects. Identification of functional compounds and its immune-modulating activities from vegetables In order to maintain the appropriate immune function, it is convenient and effective to intake immune-modulating foods in daily life. We are planning to identify the functional compounds from vegetables in Shinshu, evaluate their biological activities, and elucidate the mechanisms of immune regulation. A B C D A B C Food Science and Biotechnology Division The effect of dietary restriction on immune function Dietary restriction has been shown to delay immune senescence. However, the mechanisms of the gene expression has not been fully identified by dietary restriction. We focus on the alteration of gene expression following dietary restriction and investigate the mechanisms of suppression of immune senescence. Pursuing of immuno-improving foods is important for human healthImmunedysfunctionEnvironmentalpollutionStressDietaryhabitsAgingSmokingScreening of novel immuno-improving foods which have functional moleculesObesityAllergy,Cancer,Infection・・・Immuno-improving foodsand dietary habitsBrassica rapaL.Caloric restrictionIFN-g↑Immunesenescence↓Immunomodulatory effectsProcyanidinsanti-inflammatoryAzukibeanIFN-g↑IFN-g↑Japanese pickled vegetables ControlCaloricrestriction
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