繊維学部研究紹介_2018_英語版
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56Department of Applied BiologyTo investigate the characteristics of the biological material, to develop a new medical deviceDecellularized tissues are prepared from biological tissues, and are clinically used in Europe and U.S. The decellularized materials show biocompatibilities at implanted sites. It is possible to transplant animal tissues to humans by decellularization treatments. The object of our research is an application and an investigation of these decellularized tissue properties for use in medical devices. The vacuum pressure impregnation technique is able to easily rehydrate materials. Our research aims to fabricate a new medical material using this technique.After receiving a doctorate in Tokyo Medical and Dental University, Assistant Professor Negisih worked as a JSPS post doctor at Sapporo Medical University before coming ADEKA as a research worker. His areas of research are biological materials.Biological materials such as a decellularized material are able to mimic complex structures of animal tissues and can be used as a remodeling material by patients’ own cells. It would be possible to fabricate tissues and organ in vitro by combining these materials and stem cells. Using other led techniques may lead a novel medical device fabrication. Outlook for researchStudents learn to think by themselves and take initiative in this research lab, and this prepares them to work by well in groups or by themselves. They are equipped to pursue careers across a variety of scientic elds.Outlook for students after graduation(Left) A native porcine artery after 3 days in rat carotid transplantation. (Right) A decellularizzed porcine artery after 2 weeks in rat carotid transplantation. (A) A freeze-dried aorta after 10 min immersion into PEG. (B) A freeze-dried aorta after PEG hydration by vacuum pressure impregnation (VPI). The VPI treated aorta showed homogeneous rehydration.Jun NegishiAssistant ProfessorNative porcine artery: occlusionDecellularized porcine artery: patentDepartment of Applied BiologyHow can spider and silkworm spin such a tough silk?Silk is used as a structural material in nature such as a lifeline of spider and a shell of silkworm. The thickness of spider silk is approximately one tenth of human’s hair. The spider silk with 3-mm thickness can support a man with 60 kg. Silk seems very attractive when used as structural material, however, it is difficult to synthesize an artificial silk that has both strength and extensibility like native silk. Spiders and silkworms are known to possess sophisticated spinning mechanism. I would like to share mysteries in the natural spinning systems in spiders and silkworms and take advantage of the system to synthesize artificial silk for industrial applications.Assistant Professor Yazawa got his ph.D at Tokyo Tech and came to his current position after working as a postdoctoral researcher at Yamagata university and RIKEN in Japan. He specializes molecular biology and polymer science. His nal aim is to reveal the mechanism of spinning system of spiders and silkworms.Man-made bers need to be processed at high temperature, while spiders and silkworms synthesize their silk in a mild condition. We can synthesize the articial silk by mimicking the natural spinning system and contribute to use silk as a structural material in our daily life.Outlook for researchI would like to share the excitement of tackling the science of nature, from the study of spider and silkworm silk. You will make hypothesis and perform experiments to proof the hypothesis. Hopefully, you will exert yourself in society from your research experiment at Shinshu University.Outlook for students after graduationSpiders are xed between sponges with their legs inside the sponges to extract their silks. We feel that the silk is shiny and tough .Spiders transform silk solutions into bers in their glands.Kenjiro YazawaTenure-track Assistant Professor

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