医学科研究紹介_2017-2018_英語版

8/47

7Exercise physiology to solve the current social problems !Summary of ActivityOur goal is to provide evidence-based information to solve the current social problems; global warming and advanced aging. Human beings have lived broad-ly on the earth by their high ability to adapt the hot/ cold environments by nature. However, the amenity that they acquired, including food and medical conditions, has deteriorated their ability and the waste of natural resources to attain the amenity has accelerated the depletion of the resources to cause the global warming. To cut the viscous circle, we would like to propose to reactivate their genetic resources to adapt the environments.・ To provide the strategy to prevent heat illness during exercise・ To provide the strategy to prevent lifestyle-related diseases with deterioration of physical fitness with aging・ To provide the epigenetic mechanisms for the effects of exercise trainingWe have developed e-Health Promotion System, composed of Interval Walking Training (IWT), portable calorimeter, and IT network system. By using the system, we have accumu-lated the database (DB) on the effects of 5-mo IWT in several thousand middle-aged and older people. By using the DB, we will develop a program to predict the effects of IWT to encourage the participants to continue IWT from their physical characteristics with genetic background. Thereby, we will transform medical service from treatment to prevention. Researchers to major exercise and applied physiology. Medical staff working for preventive and rehabilitation medicine. Researchers in private companies treating with health promotion food or device. Research subjectOutlook for researchOutlook for students after graduationSports Medical Sciences（Chief: Associate Prof. Shizue Masuki）Participants perform interval walking training (IWT) around their homes and visit a an internet. According to a trend graph sent back from the sever, they are instructed how to perform IWT by trainers etc.Exercise causes methylation (inactivation) of diseases.Measurements of esophageal sweat rate during cycling exer-cise. OncogenesisSummary of ActivityBy using pluripotent stem cells which can give rise to almost any cell type with special function, it is possible to cure previously untreatable injuries and dis-eases. For instance, differentiating stem cells into specialized cells with special function and implanting them when the damaged cells cannot heal itself, or even creating a complete organ in the lab and translanting them to replace a damaged organ.We are promoting researches about stem cells which hold promise for treating previously incurable diseases.・Creating Cancer Stem Cells by Reprogramming Technology To study the mechanism of carcinogenesis and develop therapeutic methods by repro-gramming cancer cells into cancer stem cells.・Development and Regeneration of Kidney To study the mechanisms that support the developmental competence of kidney germ tissues with the use of animal embryos.・ Establishment of Disease Model with Patient Specific iPS Cells To elucidate the pathogenesis of Ehlers-Danlos syndrome, a kind of heterogeneous con-nective tissue disorder.・ Functional Analysis of Epigenetic Factors in Pluripotent Stem Cells We are studying why various cells maintain those different state of differentiation, even though they have the same genetic information.The promising field of Regenerative Medicine is to restore structure and function of damaged tissues and organs. It is also possible to find a way to cure aging and genetic diseases.Many graduates are doing research works in medical fields in Universities or private institu-tions.Research subjectOutlook for researchOutlook for students after graduationHistology and Embryology（Chief: Prof. Katsunori Sasaki）and protein expressionCSC-like colony reprogrammed from reti-noblastoma cancer cells (RBC51)Ureteric buds induced from a mesone-phric duct by growth factors