医学科研究紹介_2017-2018_英語版
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23Better Future for Today’s Children and for All Generations to ComeThe department of pediatrics encompasses 8 areas of subspecialties: Allergy & Immunology, Cardiology, Endocrinology, Gastroenterology, Hematology-Oncolo-gy, Neonatology, Nephrology, and Neurology.Current areas of research in our lab include CAR T-cell therapy, elucidation and treatment of primary immunodeficiency, immunological analysis of neurological diseases, autonomic nervous function and kidney function of hematopoietic stem cell transplant recipients, and evaluation of antibody in dermatomyositis compli-cated with lung disease.・Development and clinical application of cancer immunotherapy with CAR-T cells・ Research on the cause of primary immunodeficiency and development of newiPS cell therapyWe strive to improve medical care for children and all future generations by understanding the mechanisms of disease, developing potential treatments, and gathering evidence from daily clinical practice. Your research discoveries may generate a cure for some disease!Because our department has various areas of subspecialties, graduates can gain a lot of knowledge from the doctors in each division. Graduates also integrate data from multiple sources to identify patient condition, thereby deepening their critical and creative thinking abilities as a physician and a researcher.Research subjectOutlook for researchOutlook for students after graduationPediatrics(Chief: Prof. & Chair : Yozo Nakazawa)Chimeric Antigen Receptor (CAR) T-cell Therapy We use our original “non-viral T-cell culture method” for gene engineering. This meth-od is highly and widely appreciated for its simplicity and low cost.Electroporator for gene transfectionHigh-quality medical care through teamwork with various professionsMental Health Clinic for Children(Chief: Clinical Professor Hideo Honda)PsychiatrySummary of ActivityThe Mental Health Clinic for Children is the central medical center for child psy-chiatry in the Nagano prefecture. We collaborate with local psychiatric and pedi-atric medical institutions as well as with educational institutions and social service agencies to provide care in all aspects of children’s mental health. Our research areas include clinical studies, epidemiological studies, and basic medical studies.・Development of anger management program・Cohort study using data of medical checkups for infants・Biomarkers associated with psychological distress in children with ADHD・Sleep in children with autism spectrum disorderWe aim to establish a system which enables early detection and care of children with mental health problems including neurodevelopmental disorders. Our findings may be reflected in the policies of the government, which will lead to the improvement of the care system for children’s mental health. Career options include engagement in clinical practice and research at the Mental Health Clinic for Children, clinical practice as a child psychiatrist in medical institutions, employment in educational institutions or social service agencies, and careers at research institutions.Research subjectOutlook for researchOutlook for students after graduationWeekly meeting discussing research topicsSocial skills trainingConference presentation(in Seoul) iPS cellsBlood cellsHematopoietic lineage differentiationWe assess patient condition by creating iPS cells from patients with immune dis-ease, and inducing those cells to differen-tiate into blood cells.

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