医学科研究紹介_2017-2018_英語版

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19Leading amyloidosis center in JapanTeam Amyloidosis（Chief: Associate Prof. Yoshiki Sekijima）Medicine IIISummary of ActivityAmyloidosis is an intractable disease in which abnormal protein, called ‘’amyloid’’, deposit into multi visceral organs and cause organ dysfunction.It is sometimes very difficult to diagnose and/or treat amyloidosis appropriately. Our department is one of the leading amyloidosis center in the nation, providing total services such as disease consultation, diagnosis, research, and treatment, especially in the field of two major types of amyloidosis, ATTR and AL amyloido-sis.・Liver transplantation and pharmacological treatment for ATTRm amyloidosis.・AL amyloidosis treatment using novel chemotherapeutic agents.・Development of whole body amyloid imaging technique using PiB-PET .・Neurophysiological evaluation and analysis of amyloid neuropathy.・ Detection of rare types of amyloidosis using laser micro dissection and mass spectrome-try.Much common diseases such as Alzheimer Disease and type 2 diabetes are other kinds of amyloidosis. Our research works might lead to unveiling and overcoming of these popular diseases as well as a kind of rare types of amyloidosis.The both ways to a brilliant future as generalist and/or amyloidosis specialist are provided. Research subjectOutlook for researchOutlook for students after graduationDevelopment of novel pharmacological treatment mechanism focusing on the stabili-zation of precursor TTR tetramer protein.Diagnostic method for detecting whole body amyloid deposition using PiB-PET.Brain Disease Research（Prof. K Yoshida, M Yamada and A Nakamura）Medicine IIISummary of ActivityTo research what is happening in the brain of individual patients with neurode-generative disease, we have been conducting molecular genetic, biochemical and pathological analyses. We are also aiming to develop the robotic wear to support walking, and communication assistive device.Intractable neurodegenerative diseases are now “incurable”, however, some of them would become “treatable or reparable” in the near future.・ Elucidation of diagnostic molecular pathology of amyotrophic lateral sclerosis, spinocere-bellar degeneration and multiple system atrophy.・ Personalized robotic-wear assisted rehabilitation for patients with cerebrovascular diseas-es and neurodegenerative diseases.・Development of communication assistive device.The elucidation of diagnostic molecular pathology leads to development of disease modifying drugs. Medical application of robot technology shall enable patients with intractable disease to move and speak freely.It’s up to you to decide which ways you will choose.Research subjectOutlook for researchOutlook for students after graduationRobotic wear curara® supports walking smoothness (a collaborative research with Faculty of Textile Science and Faculty of Engineering, Shinshu University, and Kakeyu-Misayama Rehabilitation Center)Nueropatholigical examinationLaser micro dissection and following mass spectrometry for detection of rare amyloidosis.Communication support: eye tracking and electroencephalogram monitor