医学科研究紹介_2017-2018_英語版

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18Feel the Dynamism of HematologyHematology（Chief: Senior Assistant Prof. Hideyuki Nakazawa）Medicine IISummary of ActivityDespite their rarity, hematological malignancies remain to be challenging to most of the clinicians, and understanding of the pathophysiology and development of novel therapeutic strategies are the matter of urgency for many researchers. Among them, Aggressive NK Cell Leukemia, ANKL, is a representative example with less than three month over all survival after diagnosis. While our team of hematologists have actively treated ANKL patients with hematopoietic stem cell transplantation, we have proactively led international studies to clarify the genetic mechanisms of NK cell malignancies, including ANKL, together with medical institutions in Finland, Taiwan, and Korea. Most recently, we are working on the pathophysiology of Pure Red Cell Aplasia and its related disorders complicated with Large Granular Lym-phocytic Leukemia. We are also active about multicenter studies to develop novel therapeutic strategies including hematopoietic stem cell transplantation. ・genetic analysis of refractory hematological malignancies・development of hematopoietic stem cell transplantation for hematological malignancies・development of therapeutic strategies for natural killer cell malignancies・ Clinical and genetic research for Large Granular Lymphocytic Leukemia and its related disordersUnderstanding the pathophysiology of a disease may lead not only to development of a novel therapy or a new diagnostic tool, but also to refinement of the definition of the disease entity itself. It’s a thrill and excitement of hematology that you can feel such dynamism in your research and clinical work every day. ・ It is encouraged to hold proactive motivation to lead as a researcher or a clinician in our team or through corporative studies with other medical institutions・ Self-development is encouraged to be a specialist with research-oriented mind in clinical hematologyResearch subjectOutlook for researchOutlook for students after graduationExplore the whole body!Be generalist with specialized skills!Summary of ActivityDepartment of Medicine (Neurology and Rheumatology) is focusing on the development of skills to ex-plore the patients’ whole body. In the Neurology area, our target is total nervous system of the whole body which consist of the brain, spine, peripheral nerve, and muscles. There are many neurological disorders which do not show any abnormality in blood tests or imaging examination. Therefore it is very important to make a correct diag-nosis through the whole body physical examinations and neurological examinations.In the Rheumatology area, we see the patients with connective tissue disorders which mainly involve the whole body joints. You might be able to get the ability to find abnormal joints by touching and feeling the patients’ joints by your own hands. Amyloidosis is a disorder characterized by the deposition of abnormal protein called ‘amyloid’ into the whole body, such as the brain, heart, kidney, liver, digestive tract, peripheral nervous system, muscles, and endocrine systems. These visceral organs are also involved among the patients with rheumatic dis-eases. Therefore, you may get the specialized skills as an neurologist and rheumatologist and also get the gen-eral skills to see and manage the patients’ whole body issue.See following pages to check the details of our research works.▶Chief: Chief of Neurology: Yoshiki Sekijima (associate Prof.) Chief of Rheumatology: Yasuhiro Shimojima (associate Prof.)▶Divisions: 1. Amyloidosis team 2. Brain Disease Research team 3. Muscular disorder team 4. Rheumatic disorder teamMedicine III(Neurology and Rheumatology)Organizing staff of Matsumoto Meeting of Japanese Society of Hematology in July, 2017hamatopathologic conferenceAt Annual Meetings of Amecican Society of Hematology