保健学科_研究紹介2017-2018(英語)

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―25―Medical TechnologyObtaining an overview of the spread of drug-resistant bacteria High prevalence of antimicrobial resistance among Gram-negative bacteria has posed an urgent and global threat in clinical and public health settings during the last few decades. Our research focuses on analyzing the complexities of the antimicrobial resistance mechanism, allowing us to discover clinically important resistant bacteria. We have broadened our scope of research interests to include food, food-producing animals, companion animals, and the ecological environment for exploring transmission, circulation dynamics and control measures of antimicrobial resistant bacteria. Group B streptococcus (GBS) is one of the most important causes of life-threatening infections, such as sepsis or meningitis in neonates. Our study group has also conducted leading researches on GBS isolates with reduced susceptibility to penicillin (PRGBS), which is the rst-line antibiotic for GBS disease therapy and for intrapartum chemoprophylaxis.During Earth’s history, microorganisms like bacteria successfully survive by evolutionary diversication such as horizontal DNA transfer in the natural environment. Analysis of the dynamics of the antimicrobial-resistant bacteria and resistance gene pool in an environment is critical for our contribution to resolving the antimicrobial resistance problem confronting humankind.Be proactive in planning your research agenda, designing an appropriate approach, and doing careful and precise experimental work. Improve your ability to think logically and to express your own views so that you can provide multifaceted discussion of your research ndings. All of your efforts will surely be rewarded in your future work.Biomedical LaboratorySciencesOutlook for researchOutlook for students after graduationJoined the Faculty of Medicine at Shins-hu University in 2014. With decades of experience in clinical microbiology labo-ratory, his research interests include antimicrobial drug resistance, molecular epidemiology, and GBS infection.Professor Noriyuki NaganoCo-existing with a very small organism(bacteria) which is invisible to the eyeOn earth, there are many invisible microorganisms inhabiting the environment as well as within our bodies. Most of these microorganisms are harmless and sometimes are even benecial to us. But some of them are not harmless and can do damage to the human body. It is important to know how to control these microorganisms. Recently, water storage tanks have been increasingly used to store rainwater. Bacteriological contamination of this rainwater can cause damage to our health. In order to use rainwater retention systems safely, our research is pursuing a method for controlling bacteria. In addition, together with the high school students who developed the LF (low-frequency) plasma jet generator, we are working on a study of sterilization technology.Completed Doctor Course, Shinshu Uni-versity, Graduate School of Engineering Sciences. Appointed as Associate Professor in 2015 after working as Assistant Profes-sor of Shinshu University School of Health Sciences.Associate ProfessorKozue OanaBacteria are very small organisms that must be seen with a microscope as they are invisible to the naked eye. Sometimes, they are harmful to us. However, bacteria and humans have always co-existed. In some cases it is necessary to reduce or kill the number of bacteria. While studying the control method of bacteria, we learn to co-exist with these organisms.As a medical technologist, you can work in various elds such as bacteria examination, physiological examination, pathology exam-ination, specimen examination, etc., and not only in hospitals, but also at examination centers, companies and universities. It is fun to meet such active graduates during academic society meetings, etc.Outlook for researchOutlook for students after graduationMedical TechnologyBiomedical LaboratorySciencesCollege students and high school students jointly conduct experiments on the sterilization effect of LF plasma jet.LF plasma is generated byapplying voltage to helium gas.Strains used for experiments are stored at -80℃ and restored on use.Novel chimeric β-lactamase rst reported by our group reveals the natural potential of an alternative mechanism, homologous recombi-nation for the diversication of CTX-M-type β-lactamases.Phenotypic screening of antimicrobial-resistant bacteria (top), and detection of resistance plasmids (bottom). - (ESBL) (CPE)ESBLCPEB , ()2014 46 - - Approach for understanding transmission/circulation dynamics of antimicrobial-resistant bacteria in environments surrounding humans.