保健学科_研究紹介2017-2018(英語)
24/40

―22―Establishment of effective diagnostic procedures for amyloidosesAmyloidosis is representative of protein misfolding disorders, in which degenerative bril proteins, known as amyloid brils, deposit on the various tissues, resulting in multi-organ failure. To date, more than 30 different types of amyloidoses have been reported and effective therapies have been established for some types of amyloidoses. Therefore, of particular importance is to make a correct diagnosis in the very early stage of the disease. Our research aims are to elucidate the pathomechanism of development of amyloidosis and to establish effective diagnostic procedures by investigation of human tissue samples containing amyloid brils.Graduated from Shinshu University School of Medicine (MD) in 1992. Research Fellow at Indiana University, Indiana, USA, from 1999-2002.Associate Professor 2011, and Professor at present position from 2017.ProfessorMasahide YazakiFurther investigation and elucidation of pathophysiology of amyloi-dosis may allow us to transmit new prevention methods of amyloid formation or seeds of new therapeutic approach for amyloidosis to the world.The majority of protein misfolding diseases including amyloidosis have been recognized as intractable disorders. Through the research on amyloidoses, I expect that students can discover new research or therapeutic methods for various protein misfolding diseases.Outlook for researchOutlook for students after graduationMedicalTechnologyClinical LaboratorySciencesMedicalTechnologyDevelopment and verication of a non-invasive and simple wearableI teach physiology, pulmonary function testing and medical electronics, and am also engaged in outpatient clinic of pulmonary medicine at Shinshu University Hospital. Our research is to clarify the pathophysiology of chronic obstructive pulmonary disease (COPD), asthma and sleep disorders, and also to develop a non-invasive wearable in cooperation with other departments and companies. We are going to develop a new method for the measurement of lung compliance, the assessment of sleep quality, and the continuous monitoring of blood pressure and glucose by analysis of pulse wave using a photo-plethysmography or ber Bragg grating (FBG) sensor.The construction of a local comprehensive care system will advance with time. It may be one tool for early detection and observation of illness, as well as for easy maintenance and promotion of health to obtain health information in individuals using non-invasive wearables, which will be connected to extend healthy life expectancy.After graduation, most students work as medical technologists in local core hospitals while some students choose the way of a medical equipment maker or clinical engineering. We all want to contribute to medical development using the knowledge and skills learnt at Shinshu University.Clinical LaboratorySciencesOutlook for researchOutlook for students after graduationGraduated from Shinshu Univ. School of Medicine, and worked at 1st Dept. of In-ternal Medicine, and then studied abroad in the USA after acquiring doc-toral degree. Appointed to present posi-tion in 2008.Professor Keisaku FujimotoNow developing a non-invasive apparatus for measurement of lung compliance using a combination of photo-plethysmograph of pulse and spirometer. This is the rst such trial in the world.Non-invasive monitoring of vital signs (respiration, pulse wave, blood pressure, blood sugar, stress, stiffness of arteries, activity (energy consumption), sleep quality, sleep disordered breathing, and monitoring fetal movement and cardiac sound) at hospitals, nursing and care facilities, and in the home.Cardiac amyloidosisRenal amyloidosis (Heavy chain amyloidosis)Amyloid brils on the mesangium of a kidneyMedical TechnologyEstablishment of effective diagnostic procedures for amyloidosesAmyloidosis is representative of protein misfolding disorders, in which degenerative fibril proteins, known as amyloid fibrils, deposit on the various tissues, resulting in multi-organ failure. To date, more than 30 different types of amyloidoseshave been reported and effective therapies have been established in some types of amyloidoses. Therefore, of particular importance is to make a correct diagnosis in very early stage of the disease. Our research aims are to elucidate the pathomechanismof development of amyloidosis and to establish the effective diagnostic procedures by investigation of human tissue samples containing amyloid fibrils. The majority of protein misfolding diseases including amyloidosis have been recognized as intractable disorders. Through the research on amyloidoses, I expect that students can discover the new research or therapeutic methods for various protein misfoldingdiseases. Cardiac amyloidosisAmyloid fibrils on the mesangiumof kidneyFurther investigation and elucidation of pathophysiology of amyloidosis may allow us to transmit new prevention methods of amyloid formation or seeds of new therapeutic approach for amyloidosis to the world. ClinicalLaboratorySciencesGraduated from Shinshu University School of Medicine (MD) in 1992. Research Fellow at Indiana University, Indiana, USA, from 1999-2002. Associate Professor 2011, and Professor at present position from 2017.ProfessorMasahideYazakiOutlook for researchOutlookfor studentsafter graduationCongo RedPolarizedThioflavinTRenal amyloidosis (Heavy chain amyloidosis)guidance

元のページ  ../index.html#24

このブックを見る