保健学科_研究紹介2017-2018(英語)

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―21―Medical TechnologyBasic research on autoinammatory and infectious diseasesBasic research is a gratuitous act done from pure interest in life, but the result can be very benecial. I have discovered ASC and PHACTR 3 from basic research. Now, it is becoming clear that ASC is an adapter molecule of a novel signaling pathway of innate immunity and it is related to autoinammatory diseas-es. PHACTR3 is involved in the regulation of cell motility, and PHACTR3-related proteins are associated with the top causes of human death, such as cancer, and coronary artery disease. In addition, research on non-H. pyrori (NHP) helicobac-ters that is the cause of gastritis led to the discovery of new diagnostic markers and the elucidation of the route of infection.Who expected the information revolution several decades ago? When thinking about what is important, knowledge is important, but a research mind to see things analytically is more important. It is time to understand the cause of all diseases at the genetic level, and human beings are even trying to obtain technologies that can change the genome. Therefore, it is very important to think about “whether medical care can really contribute to human happiness”.Clinical LaboratorySciencesOutlook for researchOutlook for students after graduationGraduated from Kyushu University and Graduate School of Kyoto University. Worked at NIH NCI USA, Bio-engineer-ing Research Center of Tosoh Co., Kyo-to University until present position at Shinshu University.Professor Junji SagaraPondering the meaning and biologicalbehavior pertaining to changes in cells and tissues observed in pathological tissuesIt is fascinating and important to ponder the meaning and biological behavior pertaining to changes in cells and tissues observed in pathological tissues. Currently, it is possible to recognize abnormalities of substances and genes behind the morphological change of cells and tissues on tissue specimens. Noting that tumors composed of cells similar to the epithelial cells of the gastrointestinal tract mucosa also occur outside of the gastrointestinal tract, we have been working on a research on any substance and criteria useful for its diagnosis. H. pylori which inhabits the human gastric mucosa is believed to be a main cause of malignant gastric tumor and other types of bacteria similar to H. pylori also inhabit in the gastric mucosa of human and animals. We have been working on a research of these bacteria.Graduated from Shinshu University. Worked as pathologist at Shinshu University Hospital from 1985 to 2001. PhD from Shinshu University.Appointed as Professor from 2001.ProfessorHiroyoshi OtaSome substances may be expressed in a cell lineage-specic manner in normal and tumor tissues and common substances may be expressed in a tumor group composed of similar cells. Some of these substances have a potential in application to clinical test and treatment as well. The understand-ing of the mechanisms that underline gastric disease development mediated by other types of bacteria similar to H. pylori is essential for developing strategies for prevention and treatment of gastric diseases.The capability of recognizing the image of disorders as a change in cells and tissues is signicantly useful in various elds of medicine. In addition, it is possible to deepen understanding of diseases by considering both molecular mechanism of disorder onset and morphological change in cells and tissues as well in an integrated manner. Outlook for researchOutlook for students after graduationMedical TechnologyClinical LaboratorySciencesASC: ASC is an adaptor protein in a signal pathway of innate immunity. This signal pathway is activated by a variety of external and internal danger signals and produces IL- 1 β and IL-18.PHACTR: Phactrs are involved in cell migration. PHACTR 3 (green) is distributed in the leading edge of cells.Clinical Importance: Our basic researches are benecial for revealing the cause of human diseases.（Helicobacter heilmannii s.s.）（Helicobacter felis）Gastric tumorPancreatic tumorPulmonary tumorUterine cervical tumor1) ASCFamilial Mediterranean FeverAutoinammatory diseases2) Phactr3Myocardial infractionCancers3) NHP HelicobactersNew diagnostic markerZoonosisMedical TechnologyBasic research on autoinflammatory and infectious diseasesBasic research is a gratuitous act done from pure interest in the life, butthe result can be very beneficial. I have discovered ASC and PHACTR 3 from basic research. Now, it is becoming clear that ASC is an adapter molecule of a novel signaling pathway of innate immunity and it is related to autoinflammatory diseases. PHACTR3 is involved in the regulation of cell motility, and PHACTR3-related proteins are associated with the top causes of human death, such as cancer, and coronary artery disease. In addition, research on non-H. pyrori(NHP) helicobacters that is the cause of gastritis led to the discovery of new diagnostic markers and the elucidation of the route of infection.It is time to understand the cause of all diseases at the genetic level, and human beings are even trying to obtain technologies that can change the genome. Therefore, it is very important to think about "whether medical care can really contribute to human happiness".Who expected the information revolution several decades ago? When thinking about what is important, knowledge is also important, but a research mind to see things analytically is more important than that. ClinicalLaboratorySciencesGraduated from Kyushu University and Graduate School of Kyoto University. Worked at NIH NCI USA, Bio-engineering Research center ofTosoh Co.,Kyoto Universityuntil present position at Shinshu University.ProfessorJunjiSagaraOutlook for researchOutlookfor studentsafter graduationPHACTR: Phactrsare involved in cell migration. PHACTR 3 (green) is distributed in the leading edge of cells.ASCASC:ASCisanadaptorproteininasignalpathwayofinnateimmunity.ThissignalpathwayisactivatedbyavarietyofexternalandinternaldangersignalsandproducesIL-1andIL-18.Danger signalsInfection, cholesterol deposits etc.Familial Mediterranean FeverAutoinflammatorydiseases 2) Phactr3Myocardial infractionCancers1) ASC3) NHPHelicobactersNew diagnostic markerZoonosisClinical Importance:Our basic researches are beneficial for revealing the cause of human diseases.NLR Receptors >10Processing proIL--18(cytoplasmic)Release of IL--18