農学部研究紹介2017-2018_英語版

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Laboratory of Applied Reproductive ScienceIkuoTOMIOKAAssistantProfessorKeywords:AnimalReproduction,AssistedReproductiveTechnique(ART),ReproductiveTechnology,GeneEngineering,NeuroScience,FoodScience.Our laboratory has the following ongoing projects:1.Development of novel reproductive techniques relating to in vitrofolliculogenesis, IVM/F/C, and ES/iPScells. 2.Generation of animal models for human disease using transgenicand gene modifying techniques.3.Discovering the functional food ingredients which have anti-agingeffects on somatic stem cells.1. Development of novel reproductive techniques.In vitro growth of isolated ovarian follicles is an emerging technology for fertility treatment. Novel reproductive techniques will provide solutions for the problem of infertility in human and poor reproductive efficiency in domestic animals.DCFig. 1.Microscopy with micromanipulator (left) and manipulation of mammalian embryo (right).Fig. 2. Common marmoset (left) and its embryonic stem cells (upper right), induced pluripotent stem cells (lower right).Division of Animal Science2. Generation of animal models for human disease.In medical research, many kinds of transgenic animals have been produced to model human disease and they provide indispensable tools for studying disease mechanisms and therapies in vivo.3. Discovering the functional food ingredients.To maintain our health, preventive medicine has attracted a lot of attention in recent years. The one of most important factors in preventive medicine is food environments. Discovering the functional food will contribute to human health.15Laboratory of Animal PhysiologyShinichiYONEKURAAssociateProfessor/Skeletalmuscle/Mammarygland/Neurodegenerativedisease/Cellbiology/MolecularBiologyCurrentresearchinourlabfocusesonunderstandinggrowthanddevelopmentatthecellularleveltoidentifymethodstoimproveefficiencyofanimalproduction.Regardingtheanimalproduction,currentlytherearetwomajorfocusesinthelaboratory.Thefirstistounderstandthemolecularmechanismofskeletalmuscledevelopment.Thesecondfocusinthelaboratoryistodeterminethemolecularmechanismofmammaryglanddevelopment.Inaddition,weareinvestigatingthemolecularmechanismofneurodegenerativediseaseandtryingtofindoutthepreventionfactorsforthesediseases.Molecular mechanisms of skeletal muscle developmentABCDABCMice and Drosophilaas a model for studying about the molecular mechanism of mammary gland development and neurodegeneration.Tissue culture experiments are necessary for understanding at molecular basis. Right picture indicates myotubeformation after myogenicstimuli. Division of Animal ScienceMolecular mechanisms of mammary gland developmentMolecular mechanisms of neurodegenerative disease and explore the prevention factorsMammaryglandNeuron（写真一枚or複数枚組み合わせ）活性ありDay 0Day 4Tissue culture experimentin vivo experiment (Mice, Drosophila)