農学部研究紹介2017-2018_英語版

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Chemical Biology LaboratoryJunkoOHKANDAProfessorDr. Ohkanda’ s research interests include bioorganic chemistry, medicinal chemistry, supramolecular chemistry, chemical biology, and new strategies in medicinal chemistry.AppropchesintheOhkpndpLpbinclude:Intracellulargenerationofagentsthatdisruptproteininteractions.Westudyanewapproachofintroducinglargemoleculesbyexploitingtemplatesynthesisonthetargetedproteinsurfaces.Designofbivalentinhibitorsforsimultaneousrecognitionofpocketandsurfaces.Byanchoringintoapocket,ourstrategyaimstodeliveraminimallysizedinhibitortoafeaturelessproteininterface.Elucidationofthemechanismofactionofnaturalproduct-basedantitumoragents.Weworkonchemicaltransformationoffusicoccins,aphytotoxin,toexploreanewseriesofantitumoragentsandtounderstandhowitworksincells.CDMultuvalentmoleculesgeneratedeyassemelungofsmallmodulesarecapaeleofmodulatuonofuntracellularproteununteractuons.Division of Bioscience and BiotechnologyABCDACTheOhkandaResearchLabfocusesontheproblemsthatlieattheinterfaceoforganicchemistryandbiology.Weareparticularlyinterestedinthefieldofmolecularrecognitionanditsapplicationtostructure-baseddesignofpharmaceuticalagentsandchemicaltoolsthatareusefulforbetterunderstandingimportantcellularprocesses.Amajorrecentareaofresearchofthegroupincludesthedesignofmoleculesrangingfromlow-molecular-weightenzymeinhibitorstomid-sizedagentscapableofrecognitionofproteininterfacestocontrolproteininteractions.Peptides,naturalproducts,heterocycles,andmetalcomplexesareofinterestasthebuildingblocksforrationaldesigningofartificialbiomolecules.Laboratory of Carbohydrate ChemistryHitomiICHINOSEAssistantProfessorProteinBiochemistryEnzymologyGlycoscienceHemicellulosePectionThe research group has a present focus on the bacterial enzymes related to degradation of polysaccharides, especially plant-derived non-cellulosic polysaccharides. We aim at developing enzymatic tools and utilizing carbohydrate resources.Fundamental studies and applications of carbohydrate-related enzymesCDPurification of native and heterologouslyexpressed enzymes.Biochemical characterization of enzymes.Division of Bioscience and BiotechnologyEnzymatic modification of carbohydrate materials (seaweed galactan, arabinogalactan, pectin etc.)修士課程久志本尚子さん国際会議での受賞（USA）右は世界的に著名な研究者Dr.シャヒディ氏ABCDABC10