農学部研究紹介2017-2018_英語版

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【Polyphenol rich white rice】Laboratory of Chemistry for Functional BiomoleculesTomoyuki FUJITA, Ph.D.ProfessorSpecific area of expertise: Food chemistry and Chemistry of natural products.Key words: Structure elucidation, Bioactive molecules, Food processing, High-hydrostatic pressure. Naturalcompoundsfromediblenaturalresourcesprovideunlimitedopportunitiesfornewfoodingredientsforhealthpromotionanddiseaseprevention.Ourlaboratoryhasundertakenexploringunknownbioactivecompoundse.g.enzymaticinhibitorsfromedibleplantsandmushroomsandelucidatingtheirchemicalstructures.Additionallyweattempttousehigh-hydrostaticpressureequipmenttoproposenewapplicationsforincreasingfunctionalityoffoodstuffsandunusedbioresources.Screening for bioactive compounds on enzymatic inhibitors such as lipase and xanthine oxidase from edible plants and mushrooms.ACHigh-performance liquid chromatography system for quantitative analysis of food ingredientsHigh-hydrostatic pressure (~100MPa) equipment for processing of grains and fruits Division of Bioscience and BiotechnologyUtilization of high-hydrostatic pressure (HHP) technique for food processing of grains and fruits and for enzymatic reaction.【Brown rice】HHPpolishedLaboratory of Bioorganic ChemistryHidefumiMAKABEProfessorKeywordsorganicsynthesis,naturalproducts,bioactivecompounds,Structure-activityrelationships,organometallicsTheresearchinourgroupisfocusedaroundthechemistryofbiologicallyactivenaturalproducts:synthesis,structure-activityrelationships,biosynthesis,biosyntheticinhibitors,isolationandstructureelucidation.Developmentofnovelchemicalreactionusingorganometallicsisalsostudied.Synthesis of biologically active polyphenolsWehavegreatinterestinpolyphenolsbecauseoftheirpotentbiologicalactivities.Thus,wehavesynthesizedthesemoleculesforanalysisoftheirstructure-activityrelationships.ABCDABCAntitumor activity of procyanidinB3 and prodelphinidinB3 against human PC-3 prostate cancer cell lines. ProdelphinidinB3 which has pyrogallolmoiety (red colored) possesses significant activity.NMR is essential tool to elucidate the structure of organic compounds.Division of Bioscience and BiotechnologySynthesisofnaturalproductsusingorganometallicsStereoselectiveaminopalladationandoxypalladationareveryimportantapproachesforthesynthesisofvariousnaturalproductswhichcontainN-andO-hetero-alicycles.WeaccomplishedthesynthesisofnaturalproductsusingPd(II)-catalyzedstereoselectivecyclization.Not activeactive（写真一枚or複数枚組み合わせ）Structural elucidation using NMR9