農学部研究紹介2017-2018_英語版

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Laboratory ofEvolutionary GenomicsShunsuke SUZUKI, PhD.Assistant ProfessorKeywords:Human Evolution,Non-coding RNAs,Retrotransposons,Genome Editing,Genomic ImprintingOurresearchesfocusontherolesoftransposableelements,whichwerespecificallyacquiredinthehumanlineage,intheevolutionofhumangeneregulationandgenomicdisorders.UsinggenomeeditingtechnologybyCRISPR/CASsystem,weproducegeneticallymodifiedhumancelllinestoinvestigatefunctionofhuman-specificretrotransposedsequences.Wealsoanalyzefunctionofnewlydiscoveredhuman-specificlongnon-codingRNAsbyoverexpressionandknockdownexperimentsinvitro.•Identification and functional analyses of novel RNA transcripts associated with human-specific retrotransposedgene copies.•Analyses of function and evolutionary impact of novel human-specific long non-coding RNAs.•Analyses of the potential role of human-specific retrotransposonsin regulation of the human genome.•Analyses of the evolution of genomic imprinting in mammals.CDGenerating a genetically modified human cell line by gene manipulation. Each research project is performed by a small research group.Division of Bioscience and Biotechnology8Laboratory of Biochemistry and Molecular Cell BiologyHiroshi FUJIIProfessorKey words:・Genome expression・Nuclearreceptor・Epigeneticregulation・Signal Transduction・Metabolism Recent studies have shown that the etiology of most human diseases such as life-style related diseases and cancers are derived from complex interactions of target genes with environmental factors; however, the molecular bases of these interactions remain unclear. Since age-related diseases are likely to increase in the near future, both basic research and development of therapeutic reagents are necessary for prevention. Most of these diseases are caused by disruption of signaling networks of cell growth and differentiation, metabolism, inflammation and immune systems. Our laboratory aims to establish the molecular basis for the etiology of these diseases by analyzing signaling networks to develop their prevention and treatment.CDAnalysis of regulatory mechanisms of genome expression and its functions in human cancer cellsDivision of Bioscience and Biotechnology(1) Elucidation of regulatory mechanisms of genome expression, its function and their application(3) Elucidation of regulatory mechanisms of stem cell homeostasis and its application for regenerative studies.(2) Elucidation of regulatory mechanisms of nuclear receptor-mediated signaling in various diseasesHigh expression of FABP5 promotes cell growth and metastatic potential of cancer cells