農学部研究紹介2017-2018_英語版

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Laboratory ofFood ChemistryTakakazuMITANIAssistantProfessorResearchkeywords:Obesity-associateddiseases,Adipogenesis,Adipokines,AdipocytedifferentiationNutritionalfactors,Foodfunctions,TheresearchinterestsoftheLaboratoryofFoodSciencefocusonthediscoveryanddevelopmentofNutraceuticalsandnovelactivecompoundsthatcanbeusedfordrugsorfunctionalfoods.Ourlaboratoryaspirestofostertheharmoniousdevelopmentofhumannatureandscience,producingworldclassresearchoutputs,andcultivatingnewscientistswithcreativityandinternationalitywhowillcontributetosocietythroughresearchandeducation.Obesity is one of the risk factors for type 2 diabetes and cardiovascular diseases, but also dementia. Thus, we focus on obesity to prevent the above-mentioned diseases. 3T3-L1 cells are model of adipocytes. We have searched the anti-adipogenesis and anti-obesity compounds using this cells.Furthermore, we have characterized molecular target in adipocytes for active compound against obesity.Division of Bioscience and BiotechnologyAnalysis of molecular mechanism of anti-obesity active compounds, and Identification of the molecular targets of these active compounds. Development of a therapeutic agent for obesity and obesity-associated diseases.Differentiation to adipocytesCell lysatesRes-bound resinResInputPull down−++++++Resveratrol (Res)Laboratory of Applied Mushroom ScienceMasakiFUKUDAProfessorMushroom geneticsMushroom breedingMushroom phylogenyGenetic resourcesMutant strainsThedevelopmentofmushroomcultivarswithsuperiorpropertiessuchashighfruitingbodyproductivity,diseaseresistance,andhumanhealthbenefitswillbeveryimportantforpromotingcommercialproduction.Todevelopthesuperiorcultivarsusingmushroomgeneticresources(e.g.,wildstrainsandcultivars),wearecarryingoutphylogeneticanalysesforexamininggeneticrelatednessbetweenbreedingmaterialsincludingthegeneticresources.Wearealsoisolatingusefulmutantstrains(e.g.,albinoandspore-deficientstrains)forcultivatedmushrooms.Estimation of genetic relationships among mushroom strains in natural populationsCDAfter collecting mushroom genetic resources, isolating mycelial cultures, and preserving mushroom strains, we are developing superior cultivars using the strains.A: Students are performing mushroom genetic studies in the Laboratory. B: Protoplasts from PleurotusostreatusC: DNA fingerprints for FlammulinavelutipesDivision of Bioscience and BiotechnologyDevelopment of mutant strains for mushroom cultivarsDevelopment of breeding techniques for Himematsutake(Agaricusblazei＝A. subrufescens)自動収穫機によって根が均一に切断されたホウレンソウ2. Mycelium isolation culture1. Collection of mushroom genetic resources5. Selection of superior cultivars3. Preservation of mushroom genetic resources4. Evaluation ofgenetic resourcesABC6