Regulation of Blood Pressure during Exercise: Implications for the Role of Dopamine-O-Sulfoconjugate
【Supercategory：7. DESCENTE SPORTS SCIENCE Subcategory：7.5 Vol.5】
1. Dopamine sulfoconjugated isomers were synthesized chemically and used for determinations of them in urine.
2. Dopamine-O-sulfoconjugate and free adrenaline, noradrenaline and dopamine in urine were determined by high-performance liquid chromatography.
3. Increase of systolic blood pressure during exercise (3 km running) was associated with parallel increase in the free noradrenaline excretion in urine.
4. Excretion of dopamine-3-O-sulfoconjugate 1hr after the cessation of exercise decreased to lower levels (1.7±0.6 nmol/min) than that of pre-exercise levels (2.3±0.5 nmol/min).
5. Negative phase response of systolic blood pressure for recovery of exercise was correlated with dopamine-3-O-sulfoconjugate excretion.
DESCENTE SPORTS SCIENCE Vol.5/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
2. Dopamine-O-sulfoconjugate and free adrenaline, noradrenaline and dopamine in urine were determined by high-performance liquid chromatography.
3. Increase of systolic blood pressure during exercise (3 km running) was associated with parallel increase in the free noradrenaline excretion in urine.
4. Excretion of dopamine-3-O-sulfoconjugate 1hr after the cessation of exercise decreased to lower levels (1.7±0.6 nmol/min) than that of pre-exercise levels (2.3±0.5 nmol/min).
5. Negative phase response of systolic blood pressure for recovery of exercise was correlated with dopamine-3-O-sulfoconjugate excretion.
DESCENTE SPORTS SCIENCE Vol.5/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
| Researcher | Takanobu Yamamoto, Atsushi Yamatodani |
|---|---|
| University or institution | Department of Pharmacology H, Osaka University Medical School |
Keywords
Dopamine, systolic blood pressure, exercise, free noradrenaline excretion