The Effect of Prolonged Exercise on the Formation of Oxidized LDL and Total Antioxidant Capacity in Serum
【Supercategory：7. DESCENTE SPORTS SCIENCE Subcategory：7.19 Vol.19】
The purpose of this study was to clarify the effect of a single bout of prolonged exercise on the formation of oxidized LDL in plasma and on the total antioxidant capacity of serum.
Thirty-five male triathletes (36.7±8.8yr.), who participated in the '97 Ironman Japan in Lake Biwa (180.2km bike, 42.2km run, average race time: 9hrs 40min), were examined. Blood samples were taken before, immediately after and one day after the race to determine the level of oxidized LDL in plasma (ox-LDL), the antioxidant levels (vitamin C, α-tocopherol) in serum, and the lag time for the initiation of conjugated diene formation in serum (used as an index of total antioxidant capacity of serum).
Ox-LDL in plasma showed a significant increase immediately after and one day after the race.
Lag time for the formation of conjugated diene in serum was significantly prolonged immediately after the race. Also, lag time was positively correlated with serum vitamin C level immediately after the race. The change in plasma ox-LDL level was negatively correlated to the change in total antioxidant capacity in serum immediately after the race.
We conclude that the production of ox-LDL in plasma increased after the prolonged exercise. However, the total antioxidant capacity of serum was enhanced after the prolonged exercise in accordance with the increase of antioxidants. It may be the case when the total antioxidant capacity is sufficiently enhanced, the oxidation of LDL after prolonged exercise can be prevented.
DESCENTE SPORTS SCIENCE Vol.19/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
Thirty-five male triathletes (36.7±8.8yr.), who participated in the '97 Ironman Japan in Lake Biwa (180.2km bike, 42.2km run, average race time: 9hrs 40min), were examined. Blood samples were taken before, immediately after and one day after the race to determine the level of oxidized LDL in plasma (ox-LDL), the antioxidant levels (vitamin C, α-tocopherol) in serum, and the lag time for the initiation of conjugated diene formation in serum (used as an index of total antioxidant capacity of serum).
Ox-LDL in plasma showed a significant increase immediately after and one day after the race.
Lag time for the formation of conjugated diene in serum was significantly prolonged immediately after the race. Also, lag time was positively correlated with serum vitamin C level immediately after the race. The change in plasma ox-LDL level was negatively correlated to the change in total antioxidant capacity in serum immediately after the race.
We conclude that the production of ox-LDL in plasma increased after the prolonged exercise. However, the total antioxidant capacity of serum was enhanced after the prolonged exercise in accordance with the increase of antioxidants. It may be the case when the total antioxidant capacity is sufficiently enhanced, the oxidation of LDL after prolonged exercise can be prevented.
DESCENTE SPORTS SCIENCE Vol.19/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
| Researcher | Yukari Kawai*1, Toshihito Katsumura*1, Teruichi Shimomitsu*1, Yoshikazu Takanami*1, Chizuko Maruyama*2 |
|---|---|
| University or institution | *1 Department of Preventive Medicine and Public Health, Tokyo Medical College, *2 Department of Food and Nutrition, Japan Women's University |
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