Physical training may be effective for preventing the initiation and the promotion of the life-style related disease by ameliorating insulin resistance. To evaluate the insulin sensitivity quantitatively is the first step for medical treatment of the metabolic syndrome. In this study, clinical usefullness of measurement of the plasma glucose disappearance rate as an index of insulin resistance was discussed. Glucose disappearance rate during the 3- to 15-min period following by the insulin injection, termed as "K value", was correlated with the index evaluated by glucose-clamp techniques. It suggests that the short-time insulin loading test is suitable as a simple and safety method of insulin resistance estimation.
　Using this method, diabetics of inpatients were monitored by the degrees of insulin resistance. Some kinds of insulin resistance were detected in most of the diabetic patients, and these were partially restored by the treatment of diabetes. Also, physical training improved insulin sensitivity as the same extent as the medication. And, in these cases, reduction of visceral fat volume appeared to be more effective in restoring insulin resistance than reduction of subcutaneous fat volume. These results suggest that physical training should apply to the case of insulin resistance, and, especially, to the case of visceral fat obesity.

DESCENTE SPORTS SCIENCE Vol.21/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE