The purpose of present study was to investigate the effect of long-term behavioral modification program using exercise and/or diet therapy for 12 to 24 months on insulin resistance syndrome or metabolic fitness in 33 Japanese male subjects (52.5±11.1 y.o.) with impaired glucose tolerance (n=11) and type 2 diabetes mellitus (n=22). After intervention trial in whole groups, body mass index (BMI), visceral (VFA) and subcutaneous fat area (SFA) evaluated by CT scan, and fasting plasma insulin (FIRI) levels were significantly decreased, while estimated maximal oxygen uptake (VO₂max) was significantly increased. The physiological and biochemical parameters in good compliance group (GCG;n=17) was compared with those in poor compliance group (PCG; n=16). No significant difference in every parameters at baseline were observed between both groups. In GCG after intervention trial, VO₂max and high-density lipoprotein cholesterol (HDL-c) were significantly increased, and BMI, FIRI, area under the curve for glucose (AUCPG) and for insulin (AUCIRI) during 75g oral glucose tolerance test (OGTT) and insulin resistance score evaluated by HOMA (HOMA-IR) were significantly decreased. In PCG, although both VO₂max and HDL-c levels were significantly increased, obesity indices and glucose metabolism did not significantly change after long-term intervention trial. Intervention trial did not altered resting systolic and diastolic blood pressure in both groups. Change of log FIRI is significantly associated with changes of BMI (r=0.380) and SFA (r=0.410). The change of total cholesterol (TC) is significantly associated with changes of BMI (r=0.394), VFA (r=0.515), VO₂max (r=-0.411), log FIRI (r=0.474), and AUCIRI (r=0.483). The change of TC/HDL-c ratio is significantly related to change of VFA (r=0.414) and HOMA-IR (r=0.412). The changes of TG is significantly related to change of HOMA-IR (r=0.539). These results suggest that this program used in longterm intervention trial is useful for the improvement of insulin resistance syndrome or metabolic fitness in Japanese male subjects with glucose intolerance.

DESCENTE SPORTS SCIENCE Vol.22/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE