Effects of Exercise at Different Intensities on the Thrombotic Tendency
【Supercategory：7. DESCENTE SPORTS SCIENCE Subcategory：7.24 Vol.24】
Platelets play an important role in the pathogenesis of cardiovascular diseases. It is believed that regular low-intensity exercise can reduce the risk of cardiovascular diseases but high-intensity exercise provokes some cardiac events such as angina, myocardial infarction, and sudden death. The aim of the present study was to investigate the effects of exercise at different intensities, low and high on the basis of ventilatory threshold (VT), on platelet reactivity and coagulation using a novel in vitro method, haemostatometry.
Seven healthy young men (age: 20-29 years) performed bicycle ergometer exercise tests of 30-min duration at intensities of 90% (EX-90%VT) and 130% (EX-130%VT) to each individual VT. The exercise was performed at the same time of the day on two separate days. Blood samples were collected from the antecubital vein before (at rest), immediately after and 30 minutes after exercise. Haemostatometry: The instrument (haemostatometer) was built in the Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University and was identical with the original one described by P. Görög and I.B.Kovacs (1989-92). The unique features of this method are in using non-anticoagulated (native) blood and forming platelet-rich thrombus by shear-induced platelet activation.
Blood cell counts (erythrocytes, leucocytes, platelets), haematocrit, blood lactic acid and plasma catecholamine levels were slightly but significantly increased after EX-90%VT and markedly after EX-130%VT. Subsequently these were restored to the resting levels at 30 minutes after both EX-90%VT and EX-130%VT. Platelet reactivity and coagulation were significantly enhanced immediately after and 30 minutes after EX-130%VT. But EX-90%VT did not change significantly both platelet reactivity and coagulation.
The present study demonstrated that high-intensity exercise induced platelet hyperreactivity and hypercoagulable state, which might be related to the increased risk of cardiovascular disease by acute exercise. It was also confirmed that low-intensity exercise did not affect the thrombotic state.
DESCENTE SPORTS SCIENCE Vol.24/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
Seven healthy young men (age: 20-29 years) performed bicycle ergometer exercise tests of 30-min duration at intensities of 90% (EX-90%VT) and 130% (EX-130%VT) to each individual VT. The exercise was performed at the same time of the day on two separate days. Blood samples were collected from the antecubital vein before (at rest), immediately after and 30 minutes after exercise. Haemostatometry: The instrument (haemostatometer) was built in the Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University and was identical with the original one described by P. Görög and I.B.Kovacs (1989-92). The unique features of this method are in using non-anticoagulated (native) blood and forming platelet-rich thrombus by shear-induced platelet activation.
Blood cell counts (erythrocytes, leucocytes, platelets), haematocrit, blood lactic acid and plasma catecholamine levels were slightly but significantly increased after EX-90%VT and markedly after EX-130%VT. Subsequently these were restored to the resting levels at 30 minutes after both EX-90%VT and EX-130%VT. Platelet reactivity and coagulation were significantly enhanced immediately after and 30 minutes after EX-130%VT. But EX-90%VT did not change significantly both platelet reactivity and coagulation.
The present study demonstrated that high-intensity exercise induced platelet hyperreactivity and hypercoagulable state, which might be related to the increased risk of cardiovascular disease by acute exercise. It was also confirmed that low-intensity exercise did not affect the thrombotic state.
DESCENTE SPORTS SCIENCE Vol.24/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
| Researcher | Hideo Ikarugi*1, Masashi Shibata*2, Shiori Shibata*3, Tomomi Oishi-Taka*4, Junichiro Yamamoto*4 |
|---|---|
| University or institution | *1 Laboratory of Health and Sport Sciences, Kobe University of Commerce, *2 College of Nursing Art and Science Hyogo, *3 Kobe City College of Nursing, *4 Laboratory of Physiology, Faculty of Nutrition and High Technology Research Center Kobe Gakuin University |
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