To examine the effects of the lifestyle and bone metabolism-related gene polymorphism on changes with aging in the bone mineral density, 60 healthy subjects, consisting of 23 males (mean age, 35.2±9.7 years) and 37 females (mean age, 36.8±9.1 years), in whom the bone mineral density was measured every year at about the same time in the past 6-10 years, underwent various investigations (basic examination, exercise, nutrition), measurement (physique, physical fitness), and examination (VDR and ER gene polymorphism).
　The results were as follows.
1. In both sexes, the frequency of the VDR gene polymorphism was bb>Bb>BB and aa>Aa>AA, and that of the ER gene polymorphism was Pp>pp>PP and xx>Xx>XX, which were similar to results of past studies with Japanese subjects. 2. In women, the mean reduction rate by aging of the bone mineral density with different types of the gene polymorphism (regression coefficient by linear regression analysis, slope) was slightly higher in the hetero-types (Bb, Aa, Pp, Xx) than in the small homo-types (bb, aa, pp, xx). 3. In women, the effects of the BMI (Body Mass Index) and (walking) steps per day on the mean reduction rate by aging of the bone mineral density were slightly higher in the hetero-types than in the small homo-types. 4. These findings shown in the above 2 and 3 suggested that the stimulation level of bone was higher in the hetero-types than in the small homo-types. These findings indicated that improvement of the lifestyle and understanding one's own physique and genetic factors are important for the effective prevention and treatment of osteoporosis taking into consideration the effects on long-term changes with aging in the bone mineral density in relation to the prevention of fractures by falling.

DESCENTE SPORTS SCIENCE Vol.25/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE