Relationship between the Rate of Fat Mass Reduction and the Rebound Phenomenon − The Study about the Central Regulation of Eating Behavior −
【Supercategory：7. DESCENTE SPORTS SCIENCE Subcategory：7.26 Vol.26】
The purpose of this study was to investigate the optimal weight reduction program for the dietary and exercise therapy. We tested about the rate of weight reduction arranged by the food restriction or voluntary wheel running protocol that will effect on the central regulation of eating behavior.
Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of hyperphagia and obesity, was used in this study (19-week-old at the end of experiment). The rats were randomly assigned to either the food restriction (in the duration of 1w, 2w or 4w), exercise (in the duration of 2w or 4w) or control group.
The food volume or exercise frequency were arranged, and all rats weighed about 80% of control rats at the end of experiment.
Compared to chronic exercise, acute food restriction promoted the reduction in the value of the blood leptin concentration divided by the total abdominal fat mass (i.e. the ability of leptin secretion in adipose tissue). Food restriction, compared to exercise, provided the higher expression of neuropeptide Y mRNA in the arcuate nucleus of the hypothalamus that might induce the orexigenic behavior.
These results suggested that the exercise therapy may be more effective for weight reduction and it's maintenance compared to the dietary therapy.
DESCENTE SPORTS SCIENCE Vol.26/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of hyperphagia and obesity, was used in this study (19-week-old at the end of experiment). The rats were randomly assigned to either the food restriction (in the duration of 1w, 2w or 4w), exercise (in the duration of 2w or 4w) or control group.
The food volume or exercise frequency were arranged, and all rats weighed about 80% of control rats at the end of experiment.
Compared to chronic exercise, acute food restriction promoted the reduction in the value of the blood leptin concentration divided by the total abdominal fat mass (i.e. the ability of leptin secretion in adipose tissue). Food restriction, compared to exercise, provided the higher expression of neuropeptide Y mRNA in the arcuate nucleus of the hypothalamus that might induce the orexigenic behavior.
These results suggested that the exercise therapy may be more effective for weight reduction and it's maintenance compared to the dietary therapy.
DESCENTE SPORTS SCIENCE Vol.26/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
| Researcher | Masaki Kimura*1, Toshiaki Shibasaki*1, Fumihiko Yoshie*1, Masato Suzuki*2, Hideki Yamauchi*2 |
|---|---|
| University or institution | *1 Kyoritsu University of Pharmacy, *2 The Jikei University School of Medicine |
Keywords
weight reduction, dietary, exercise therapy, hyperphagia, obesity